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The British Journal of Cancer. Supplement logoLink to The British Journal of Cancer. Supplement
. 1996 Jul;27:S145–S150.

Role of the HAP1 protein in repair of oxidative DNA damage and regulation of transcription factors.

G Barzilay 1, L J Walker 1, D G Rothwell 1, I D Hickson 1
PMCID: PMC2149983  PMID: 8763868

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Selected References

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  1. Abate C., Luk D., Gentz R., Rauscher F. J., 3rd, Curran T. Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1032–1036. doi: 10.1073/pnas.87.3.1032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Abate C., Patel L., Rauscher F. J., 3rd, Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science. 1990 Sep 7;249(4973):1157–1161. doi: 10.1126/science.2118682. [DOI] [PubMed] [Google Scholar]
  3. Amati B., Littlewood T. D., Evan G. I., Land H. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 1993 Dec 15;12(13):5083–5087. doi: 10.1002/j.1460-2075.1993.tb06202.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ames B. N., Shigenaga M. K., Hagen T. M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915–7922. doi: 10.1073/pnas.90.17.7915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barzilay G., Hickson I. D. Structure and function of apurinic/apyrimidinic endonucleases. Bioessays. 1995 Aug;17(8):713–719. doi: 10.1002/bies.950170808. [DOI] [PubMed] [Google Scholar]
  6. Barzilay G., Mol C. D., Robson C. N., Walker L. J., Cunningham R. P., Tainer J. A., Hickson I. D. Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. Nat Struct Biol. 1995 Jul;2(7):561–568. doi: 10.1038/nsb0795-561. [DOI] [PubMed] [Google Scholar]
  7. Chen D. S., Olkowski Z. L. Biological responses of human apurinic endonuclease to radiation-induced DNA damage. Ann N Y Acad Sci. 1994 Jul 29;726:306–308. doi: 10.1111/j.1749-6632.1994.tb52834.x. [DOI] [PubMed] [Google Scholar]
  8. Collins M. K., Lopez Rivas A. The control of apoptosis in mammalian cells. Trends Biochem Sci. 1993 Aug;18(8):307–309. doi: 10.1016/0968-0004(93)90042-l. [DOI] [PubMed] [Google Scholar]
  9. Demple B., Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem. 1994;63:915–948. doi: 10.1146/annurev.bi.63.070194.004411. [DOI] [PubMed] [Google Scholar]
  10. Demple B., Herman T., Chen D. S. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11450–11454. doi: 10.1073/pnas.88.24.11450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Doetsch P. W., Cunningham R. P. The enzymology of apurinic/apyrimidinic endonucleases. Mutat Res. 1990 Sep-Nov;236(2-3):173–201. doi: 10.1016/0921-8777(90)90004-o. [DOI] [PubMed] [Google Scholar]
  12. Frame M. C., Wilkie N. M., Darling A. J., Chudleigh A., Pintzas A., Lang J. C., Gillespie D. A. Regulation of AP-1/DNA complex formation in vitro. Oncogene. 1991 Feb;6(2):205–209. [PubMed] [Google Scholar]
  13. Graves R. J., Felzenszwalb I., Laval J., O'Connor T. R. Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli. J Biol Chem. 1992 Jul 15;267(20):14429–14435. [PubMed] [Google Scholar]
  14. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 1993 Apr 22;362(6422):709–715. doi: 10.1038/362709a0. [DOI] [PubMed] [Google Scholar]
  15. Lindahl T. Repair of intrinsic DNA lesions. Mutat Res. 1990 May;238(3):305–311. doi: 10.1016/0165-1110(90)90022-4. [DOI] [PubMed] [Google Scholar]
  16. Matsumoto Y., Kim K. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair. Science. 1995 Aug 4;269(5224):699–702. doi: 10.1126/science.7624801. [DOI] [PubMed] [Google Scholar]
  17. Mol C. D., Kuo C. F., Thayer M. M., Cunningham R. P., Tainer J. A. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Nature. 1995 Mar 23;374(6520):381–386. doi: 10.1038/374381a0. [DOI] [PubMed] [Google Scholar]
  18. Okuno H., Akahori A., Sato H., Xanthoudakis S., Curran T., Iba H. Escape from redox regulation enhances the transforming activity of Fos. Oncogene. 1993 Mar;8(3):695–701. [PubMed] [Google Scholar]
  19. Ono Y., Furuta T., Ohmoto T., Akiyama K., Seki S. Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease. Mutat Res. 1994 Jul;315(1):55–63. doi: 10.1016/0921-8777(94)90028-0. [DOI] [PubMed] [Google Scholar]
  20. Ransone L. J., Verma I. M. Association of nuclear oncoproteins fos and jun. Curr Opin Cell Biol. 1989 Jun;1(3):536–540. doi: 10.1016/0955-0674(89)90017-3. [DOI] [PubMed] [Google Scholar]
  21. Robson C. N., Hickson I. D. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nucleic Acids Res. 1991 Oct 25;19(20):5519–5523. doi: 10.1093/nar/19.20.5519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Seki S., Ikeda S., Watanabe S., Hatsushika M., Tsutsui K., Akiyama K., Zhang B. A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterization. Biochim Biophys Acta. 1991 Aug 9;1079(1):57–64. doi: 10.1016/0167-4838(91)90024-t. [DOI] [PubMed] [Google Scholar]
  23. Steller H. Mechanisms and genes of cellular suicide. Science. 1995 Mar 10;267(5203):1445–1449. doi: 10.1126/science.7878463. [DOI] [PubMed] [Google Scholar]
  24. Walker L. J., Craig R. B., Harris A. L., Hickson I. D. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res. 1994 Nov 25;22(23):4884–4889. doi: 10.1093/nar/22.23.4884. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Walker L. J., Robson C. N., Black E., Gillespie D., Hickson I. D. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol. 1993 Sep;13(9):5370–5376. doi: 10.1128/mcb.13.9.5370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wallace S. S. AP endonucleases and DNA glycosylases that recognize oxidative DNA damage. Environ Mol Mutagen. 1988;12(4):431–477. doi: 10.1002/em.2860120411. [DOI] [PubMed] [Google Scholar]
  27. Xanthoudakis S., Curran T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J. 1992 Feb;11(2):653–665. doi: 10.1002/j.1460-2075.1992.tb05097.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Xanthoudakis S., Miao G. G., Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):23–27. doi: 10.1073/pnas.91.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Xanthoudakis S., Miao G., Wang F., Pan Y. C., Curran T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 1992 Sep;11(9):3323–3335. doi: 10.1002/j.1460-2075.1992.tb05411.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Yao K. S., Clayton M., O'Dwyer P. J. Apoptosis in human adenocarcinoma HT29 cells induced by exposure to hypoxia. J Natl Cancer Inst. 1995 Jan 18;87(2):117–122. doi: 10.1093/jnci/87.2.117. [DOI] [PubMed] [Google Scholar]
  31. Yao K. S., Xanthoudakis S., Curran T., O'Dwyer P. J. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol. 1994 Sep;14(9):5997–6003. doi: 10.1128/mcb.14.9.5997. [DOI] [PMC free article] [PubMed] [Google Scholar]

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