Abstract
Verapamil, nifedipine, and diltiazem are drugs which decrease intracellular calcium in cardiac muscle, smooth muscle, and nodal cardiac cells. Unlike B-blockers, each drug acts at a different site on the cell membrane and has an important difference in overall action. Verapamil is used to treat angina, systemic hypertension, hypertrophic cardiomyopathy, and supraventricular and junctional tachyarrhythmias. Nifedipine is useful in angina, vasospastic disorders, and hypertension. A specific role for diltiazem is now being defined.
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Selected References
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- Giles T. D. Calcium antagonists: an overview. Angiology. 1982 Aug;33(8):489–491. doi: 10.1177/000331978203300801. [DOI] [PubMed] [Google Scholar]
- Kieval J., Myerburg R. J. The hemodynamic effects of calcium channel blocking agents: a brief review. Angiology. 1982 Aug;33(8):516–521. doi: 10.1177/000331978203300803. [DOI] [PubMed] [Google Scholar]
- Schwartz A. Symposium on Cardiovascular Disease and Calcium Antagonists. Introduction. Am J Cardiol. 1982 Feb 18;49(3):497–498. doi: 10.1016/s0002-9149(82)80001-5. [DOI] [PubMed] [Google Scholar]
- Singh B. N. Pharmacological basis for the therapeutic applications of slow-channel blocking drugs. Angiology. 1982 Aug;33(8):492–515. doi: 10.1177/000331978203300802. [DOI] [PubMed] [Google Scholar]
- Winniford M. D., Willerson J. T., Hillis L. D. Calcium antagonists in the treatment of individuals with ischemic heart disease. Angiology. 1982 Aug;33(8):522–539. doi: 10.1177/000331978203300804. [DOI] [PubMed] [Google Scholar]
- Zipes D. P., Gilmour R. F., Jr Management of arrhythmias with "calcium antagonists". Angiology. 1982 Aug;33(8):540–554. doi: 10.1177/000331978203300805. [DOI] [PubMed] [Google Scholar]