Abstract
In 101 hypertensive patients, the effects of a combination of propranolol and bendrofluazide were compared with those of each drug alone. After an introductory period with a placebo, the patients received, in a double-blind randomized trial, propranolol 80 mg twice a day, bendrofluazide 2.5 mg twice a day, or both drugs together twice daily. The combination produced significantly greater reductions in lying, standing, and post-exercise systolic and diastolic blood pressure than either drug separately. Side-effects were minimal and the combination was well accepted by patients.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berglund G., Andersson O., Larsson O., Wilhelmsen L. Antihypertensive effect and side-effects of bendroflumethiazide and propranolol. Acta Med Scand. 1976;199(6):499–506. doi: 10.1111/j.0954-6820.1976.tb06770.x. [DOI] [PubMed] [Google Scholar]
- Galloway D. B., Glover S. C., Hendry W. G., Logie A. W., Petrie J. C., Smith M. C., Lewis J. A., Simpson W. T. Propranolol in hypertension: a dose-response study. Br Med J. 1976 Jul 17;2(6028):140–142. doi: 10.1136/bmj.2.6028.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mitchell I., Lodge R., Lawson A. A. Adjuvant effect of bendrofluazide on propranolol in hypertension. Scott Med J. 1972 Oct;17(10):326–329. doi: 10.1177/003693307201701003. [DOI] [PubMed] [Google Scholar]
- Petrie J. C., Galloway D. B., Webster J., Simpson W. T., Lewis J. A. Atenolol and bendrofluazide in hypertension. Br Med J. 1975 Oct 18;4(5989):133–135. doi: 10.1136/bmj.4.5989.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prichard B. N., Gillam P. M. Treatment of hypertension with propranolol. Br Med J. 1969 Jan 4;1(5635):7–16. doi: 10.1136/bmj.1.5635.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zacharias F. J., Cowen K. J., Prestt J., Vickers J., Wall B. G. Propranolol in hypertension: a study of long-term therapy, 1964-1970. Am Heart J. 1972 Jun;83(6):755–761. doi: 10.1016/0002-8703(72)90206-2. [DOI] [PubMed] [Google Scholar]