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. 1982 Mar;149(3):1171–1174. doi: 10.1128/jb.149.3.1171-1174.1982

Repression of cytosine deaminase by pyrimidines in Salmonella typhimurium.

T P West, G A O'Donovan
PMCID: PMC216515  PMID: 7037740

Abstract

The synthesis of cytosine deaminase in Salmonella typhimurium is repressed by pyrimidines. This repression is mediated by both a uridine and a cytidine compound, indicating a distinct difference in the regulation of synthesis of cytosine deaminase from the regulation of the de novo pyrimidine pathway enzymes. A salvage role for the enzyme in pyrimidine metabolism is postulated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abd-el-Al A., Ingraham J. L. Control of carbamyl phosphate synthesis in Salmonella typhimurium. J Biol Chem. 1969 Aug 10;244(15):4033–4038. [PubMed] [Google Scholar]
  2. BECKWITH J. R., PARDEE A. B., AUSTRIAN R., JACOB F. Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli. J Mol Biol. 1962 Dec;5:618–634. doi: 10.1016/s0022-2836(62)80090-4. [DOI] [PubMed] [Google Scholar]
  3. Beck C. F., Ingraham J. L., Neuhard J., Thomassen E. Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium. J Bacteriol. 1972 Apr;110(1):219–228. doi: 10.1128/jb.110.1.219-228.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beck C. F., Neuhard J., Thomassen E., Ingraham J. L., Kleker E. Salmonella typhimurium mutants defective in cytidine monophosphate kinase (cmk). J Bacteriol. 1974 Dec;120(3):1370–1379. doi: 10.1128/jb.120.3.1370-1379.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 May 7;72:248–254. doi: 10.1016/0003-2697(76)90527-3. [DOI] [PubMed] [Google Scholar]
  6. DAVIS B. D., MINGIOLI E. S. Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950 Jul;60(1):17–28. doi: 10.1128/jb.60.1.17-28.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HAYAISHI O., KORNBERG A. Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes. J Biol Chem. 1952 May;197(2):717–732. [PubMed] [Google Scholar]
  8. Justesen J., Neuhard J. pyrR identical to pyrH in Salmonella typhimurium: control of expression of the pyr genes. J Bacteriol. 1975 Sep;123(3):851–854. doi: 10.1128/jb.123.3.851-854.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kelln R. A., Kinahan J. J., Foltermann K. F., O'Donovan G. A. Pyrimidine biosynthetic enzymes of Salmonella typhimurium, repressed specifically by growth in the presence of cytidine. J Bacteriol. 1975 Nov;124(2):764–774. doi: 10.1128/jb.124.2.764-774.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Munch-Petersen A., Nygaard P., Hammer-Jespersen K., Fiil N. Mutants constitutive for nucleoside-catabolizing enzymes in Escherichia coli K12. Isolation, charactrization and mapping. Eur J Biochem. 1972 May 23;27(2):208–215. doi: 10.1111/j.1432-1033.1972.tb01828.x. [DOI] [PubMed] [Google Scholar]
  11. Neuhard J., Ingraham J. Mutants of Salmonella typhimurium requiring cytidine for growth. J Bacteriol. 1968 Jun;95(6):2431–2433. doi: 10.1128/jb.95.6.2431-2433.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nygaard P. Nucleoside-catabolizing enzymes in Salmonella typhimurium. Introduction by ribonucleosides. Eur J Biochem. 1973 Jul 2;36(1):267–272. doi: 10.1111/j.1432-1033.1973.tb02909.x. [DOI] [PubMed] [Google Scholar]
  13. O'Donovan G. A., Neuhard J. Pyrimidine metabolism in microorganisms. Bacteriol Rev. 1970 Sep;34(3):278–343. doi: 10.1128/br.34.3.278-343.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sanderson K. E., Hartman P. E. Linkage map of Salmonella typhimurium, edition V. Microbiol Rev. 1978 Jun;42(2):471–519. doi: 10.1128/mr.42.2.471-519.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Schwartz M., Neuhard J. Control of expression of the pyr genes in Salmonella typhimurium: effects of variations in uridine and cytidine nucleotide pools. J Bacteriol. 1975 Mar;121(3):814–822. doi: 10.1128/jb.121.3.814-822.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Valentin-Hansen P., Svenningsen B. A., Munch-Petersen A., Hammer-Jespersen K. Regulation of the deo operon in Escherichia coli: the double negative control of the deo operon by the cytR and deoR repressors in a DNA directed in vitro system. Mol Gen Genet. 1978 Feb 16;159(2):191–202. doi: 10.1007/BF00270893. [DOI] [PubMed] [Google Scholar]
  17. Williams J. C., O'Donovan G. A. Repression of enzyme synthesis of the pyrimidine pathway in Salmonella typhimurium. J Bacteriol. 1973 Sep;115(3):1071–1076. doi: 10.1128/jb.115.3.1071-1076.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yan Y., Demerec M. Genetic analysis of pyrimidine mutants of Salmonella typhimurium. Genetics. 1965 Sep;52(3):643–651. doi: 10.1093/genetics/52.3.643. [DOI] [PMC free article] [PubMed] [Google Scholar]

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