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. 1965 May 1;1(5443):1153–1156. doi: 10.1136/bmj.1.5443.1153

Effect of Obesity and of Starvation on Insulin Activity

N Samaan, J Brown, Russell Fraser, I Trayner
PMCID: PMC2166532  PMID: 14273518

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANTONIADES H. N., BOUGAS J. A., PYLE H. M. Studies on the state of insulin in blood. Examination of splenic, portal and peripheral blood serum of diabetic and nondiabetic subjects for "free" insulin and insulin complexes. N Engl J Med. 1962 Aug 2;267:218–222. doi: 10.1056/NEJM196208022670502. [DOI] [PubMed] [Google Scholar]
  2. BORNSTEIN J., LAWRENCE R. D. Plasma insulin in human diabetes mellitus. Br Med J. 1951 Dec 29;2(4747):1541–1544. doi: 10.1136/bmj.2.4747.1541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHRISTOPHE J., DAGENAIS Y., MAYER J. Increased circulating insulin-like activity in obese-hyperglycaemic mice. Nature. 1959 Jul 4;184:61–62. doi: 10.1038/184061a0. [DOI] [PubMed] [Google Scholar]
  4. CONN J. W., FAJANS S. S., SELTZER H. S. Spontaneous hypoglycemia as an early manifestation of diabetes mellitus. Diabetes. 1956 Nov-Dec;5(6):437–442. doi: 10.2337/diab.5.6.437. [DOI] [PubMed] [Google Scholar]
  5. CORVILAIN J., LOEB H., CHAMPENOIS A., ABRAMOW M. Effect of fasting on levels of plasma-nonesterified fatty acids in normal children, normal adults, and obese adults. Lancet. 1961 Mar 11;1(7176):534–535. doi: 10.1016/s0140-6736(61)91601-4. [DOI] [PubMed] [Google Scholar]
  6. DUNCOMBE W. G. THE COLORIMETRIC MICRO-DETERMINATION OF NON-ESTERIFIED FATTY ACIDS IN PLASMA. Clin Chim Acta. 1964 Feb;9:122–125. doi: 10.1016/0009-8981(64)90004-x. [DOI] [PubMed] [Google Scholar]
  7. FELTS P. W., CROFFORD O. B., PARK C. R. EFFECT OF INFUSED KETONE BODIES ON GLUCOSE UTILIZATION IN THE DOG. J Clin Invest. 1964 Apr;43:638–646. doi: 10.1172/JCI104949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FRASER R., JOPLIN G. F., OPIE L. H., RABINOWITZ D. The augmented insulin tolerance test for detecting insulin resistance. J Endocrinol. 1962 Dec;25:299–307. doi: 10.1677/joe.0.0250299. [DOI] [PubMed] [Google Scholar]
  9. HALES C. N., RANDLE P. J. Effects of low-carbohydrate diet and diabetes mellitus on plasma concentrations of glucose, non-esterified fatty acid, and insulin during oral glucose-tolerance tests. Lancet. 1963 Apr 13;1(7285):790–794. doi: 10.1016/s0140-6736(63)91501-0. [DOI] [PubMed] [Google Scholar]
  10. KARAM J. H., GRODSKY G. M., FORSHAM P. H. Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes. 1963 May-Jun;12:197–204. doi: 10.2337/diab.12.3.197. [DOI] [PubMed] [Google Scholar]
  11. KEKWICK A., PAWAN G. L., CHALMERS T. M. Resistance to ketosis in obese subjects. Lancet. 1959 Dec 26;2(7113):1157–1159. doi: 10.1016/s0140-6736(59)91737-4. [DOI] [PubMed] [Google Scholar]
  12. NEWSHOLME E. A., RANDLE P. J. Regulation of glucose uptake by muscle. 5. Effects of anoxia, insulin, adrenaline and prolonged starving on concentrations of hexose phosphates in isolated rat diaphragm and perfused isolated rat heart. Biochem J. 1961 Sep;80:655–662. doi: 10.1042/bj0800655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. OPIE L. H., WALFISH P. G. Plasma free fatty acid concentrations in obesity. N Engl J Med. 1963 Apr 4;268:757–760. doi: 10.1056/NEJM196304042681404. [DOI] [PubMed] [Google Scholar]
  14. RABINOWITZ D., ZIERLER K. L. Role of free fatty acids in forearm metabolism in man, quantitated by use of insulin. J Clin Invest. 1962 Dec;41:2191–2197. doi: 10.1172/JCI104678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. RANDLE P. J., GARLAND P. B., HALES C. N., NEWSHOLME E. A. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963 Apr 13;1(7285):785–789. doi: 10.1016/s0140-6736(63)91500-9. [DOI] [PubMed] [Google Scholar]
  16. ROTH J., GLICK S. M., YALOW R. S., BERSONSA Hypoglycemia: a potent stimulus to secretion of growth hormone. Science. 1963 May 31;140(3570):987–988. doi: 10.1126/science.140.3570.987. [DOI] [PubMed] [Google Scholar]
  17. SAMAAN N. A., DEMPSTER W. J., FRASER R., PLEASE N. W., STILLMAN D. Further immunological studies on the form of circulating insulin. J Endocrinol. 1962 Jun;24:263–277. doi: 10.1677/joe.0.0240263. [DOI] [PubMed] [Google Scholar]
  18. SAMAAN N., FRASER R., DEMPSTER W. J. THE "TYPICAL" AND "ATYPICAL" FORMS OF SERUM INSULIN. Diabetes. 1963 Jul-Aug;12:339–348. doi: 10.2337/diab.12.4.339. [DOI] [PubMed] [Google Scholar]
  19. SAMAAN N., STILLMAN D., FRASER R. Abnormalities of serum insulin-like activity in liver-disease. Lancet. 1962 Dec 22;2(7269):1287–1290. doi: 10.1016/s0140-6736(62)90845-0. [DOI] [PubMed] [Google Scholar]
  20. SLATER J. D., HARTOG M., FRASER R., RANTZEN B. Dexamethasone suppression test in diagnosis in Cushing's syndrome. Br Med J. 1962 Jun 9;1(5292):1584–1586. doi: 10.1136/bmj.1.5292.1584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. STEINKE J., CAMERINI R., MARBLE A., RENOLD A. E. Elevated levels of serum insulin-like activity (ILA) as measured with adipose tissue in early untreated diabetes and prediabetes. Metabolism. 1961 Sep;10:707–711. [PubMed] [Google Scholar]
  22. VALLANCE-OWEN J., HURLOCK B., PLEASE N. W. Plasma-insulin activity in diabetes mellitus measured by the rat diaphragm technique. Lancet. 1955 Sep 17;269(6890):583–587. doi: 10.1016/s0140-6736(55)92583-6. [DOI] [PubMed] [Google Scholar]
  23. WILLIAMSON J. R., KREBS H. A. Acetoacetate as fuel of respiration in the perfused rat heart. Biochem J. 1961 Sep;80:540–547. doi: 10.1042/bj0800540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. YALOW R. S., BERSON S. A. Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new sensitive immuno-assay technic. Diabetes. 1960 Jul-Aug;9:254–260. doi: 10.2337/diab.9.4.254. [DOI] [PubMed] [Google Scholar]

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