Abstract
When protein synthesis was blocked in temperature-sensitive deoxyribonucleic acid synthesis mutants of Escherichia coli at nonpermissive temperatures, it reduced the amount of apparent subsequent chain elongation to approximately half that observed in the mutants either at nonpermissive temperatures alone or when protein synthesis was blocked at the permissive temperature. Blocking protein synthesis at the nonpermissive temperatures for periods of 40 min caused the loss of ability to reinitiate deoxyribonucleic acid synthesis at the permissive temperature.
Full text
PDF






Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abe M., Tomizawa J. Chromosome replication in Escherichia coli K12 mutant affected in the process of DNA initiation. Genetics. 1971 Sep;69(1):1–15. doi: 10.1093/genetics/69.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beyersmann D., Schlicht M., Schuster H. Temperature-sensitive initiation of DNA replication in a mutant of Escherichia coli K12. Mol Gen Genet. 1971;111(2):145–158. doi: 10.1007/BF00267789. [DOI] [PubMed] [Google Scholar]
- Carl P. L. Escherichia coli mutants with temperature-sensitive synthesis of DNA. Mol Gen Genet. 1970;109(2):107–122. doi: 10.1007/BF00269647. [DOI] [PubMed] [Google Scholar]
- Dennis P. P. Effects of chloramphenicol on the transcriptional activities of ribosomal RNA and ribosomal protein genes in Escherichia coli. J Mol Biol. 1976 Dec 15;108(3):535–546. doi: 10.1016/s0022-2836(76)80135-0. [DOI] [PubMed] [Google Scholar]
- Evans I. M., Eberle H. Accumulation of the capacity of initiation of deoxyribonucleic acid replication in Escherichia coli. J Bacteriol. 1975 Mar;121(3):883–891. doi: 10.1128/jb.121.3.883-891.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hanna M. H., Carl P. L. Reinitiation of deoxyribonucleic acid synthesis by deoxyribonucleic acid initiation mutants of Escherichia coli: role of ribonucleic acid synthesis, protein synthesis, and cell division. J Bacteriol. 1975 Jan;121(1):219–226. doi: 10.1128/jb.121.1.219-226.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jackson S. F., Wentzell B. R., McCalla D. R., Freeman K. B. Chloramphenicol damages bacterial DNA. Biochem Biophys Res Commun. 1977 Sep 9;78(1):151–157. doi: 10.1016/0006-291x(77)91233-5. [DOI] [PubMed] [Google Scholar]
- Kuempel P. L. Temperature-sensitive initiation of chromosome replication in a mutant of Escherichia coli. J Bacteriol. 1969 Dec;100(3):1302–1310. doi: 10.1128/jb.100.3.1302-1310.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LARK K. G., REPKO T., HOFFMAN E. J. THE EFFECT OF AMINO ACID DEPRIVATION ON SUBSEQUENT DEOXYRIBONUCLEIC ACID REPLICATION. Biochim Biophys Acta. 1963 Sep 17;76:9–24. [PubMed] [Google Scholar]
- Lark K. G. Initiation and termination of bacterial deoxyribonucleic acid replication in low concentrations of chloramphenicol. J Bacteriol. 1973 Feb;113(2):1066–1069. doi: 10.1128/jb.113.2.1066-1069.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lark K. G. Regulation of chromosome replication and segregation in bacteria. Bacteriol Rev. 1966 Mar;30(1):3–32. doi: 10.1128/br.30.1.3-32.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lark K. G., Renger H. Initiation of DNA replication in Escherichia coli 15T-: chronological dissection of three physiological processes required for initiation. J Mol Biol. 1969 Jun 14;42(2):221–235. doi: 10.1016/0022-2836(69)90039-4. [DOI] [PubMed] [Google Scholar]
- MAALOE O., HANAWALT P. C. Thymine deficiency and the normal DNA replication cycle. I. J Mol Biol. 1961 Apr;3:144–155. doi: 10.1016/s0022-2836(61)80041-7. [DOI] [PubMed] [Google Scholar]
- Masker W. E., Eberle H. Effect of phenethyl alcohol on deoxyribonucleic acid-membrane association in Escherichia coli. J Bacteriol. 1972 Mar;109(3):1170–1174. doi: 10.1128/jb.109.3.1170-1174.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nierhaus D., Nierhaus K. H. Identification of the chloramphenicol-binding protein in Escherichia coli ribosomes by partial reconstitution. Proc Natl Acad Sci U S A. 1973 Aug;70(8):2224–2228. doi: 10.1073/pnas.70.8.2224. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pato M. L. Alterations of the rate of movement of deoxyribonucleic acid replication forks. J Bacteriol. 1975 Jul;123(1):272–277. doi: 10.1128/jb.123.1.272-277.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rodriguez R. L., Davern C. I. Direction of deoxyribonucleic acid replication in Escherichia coli under various conditions of cell growth. J Bacteriol. 1976 Jan;125(1):346–352. doi: 10.1128/jb.125.1.346-352.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Satta G., Gudas L. J., Pardee A. B. Degradation of Escherichia coli DNA: evidence for limitation in vivo by protein X, the recA gene product. Mol Gen Genet. 1979 Jan 5;168(1):69–80. doi: 10.1007/BF00267935. [DOI] [PubMed] [Google Scholar]
- Schubach W. H., Whitmer J. D., Davern C. I. Genetic control of DNA initiation in Escherichia coli. J Mol Biol. 1973 Feb 25;74(2):205–221. doi: 10.1016/0022-2836(73)90107-1. [DOI] [PubMed] [Google Scholar]
- Shapiro B. M., Siccardi A. G., Hirota Y., Jacob F. On the process of cellular division in Escherichia coli. Membrane prtein alterations associated with mutations affecting the initiation of DNA synthesis. J Mol Biol. 1970 Aug 28;52(1):75–89. doi: 10.1016/0022-2836(70)90178-6. [DOI] [PubMed] [Google Scholar]
- Shen V., Bremer H. Chloramphenicol-induced changes in the synthesis of ribosomal, transfer, and messenger ribonucleic acids in Escherichia coli B/r. J Bacteriol. 1977 Jun;130(3):1098–1108. doi: 10.1128/jb.130.3.1098-1108.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ward C. B., Glaser D. A. Analysis of the chloramphenicol-sensitive and chloramphenicol-resistant steps in the initiation of DNA synthesis in E. coli B-r. Proc Natl Acad Sci U S A. 1969 Nov;64(3):905–912. doi: 10.1073/pnas.64.3.905. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wechsler J. A., Gross J. D. Escherichia coli mutants temperature-sensitive for DNA synthesis. Mol Gen Genet. 1971;113(3):273–284. doi: 10.1007/BF00339547. [DOI] [PubMed] [Google Scholar]
- Zyskind J. W., Deen L. T., Smith D. W. Temporal sequence of events during the initiation process in Escherichia coli deoxyribonucleic acid replication: roles of the dnaA and dnaC gene products and ribonucleic acid polymerase. J Bacteriol. 1977 Mar;129(3):1466–1475. doi: 10.1128/jb.129.3.1466-1475.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zyskind J. W., Smith D. W. NOVEL Escherichia coli dnaB mutant: direct involvement of the dnaB252 gene product in the synthesis of an origin-ribonucleic acid species during initiaion of a round of deoxyribonucleic acid replication. J Bacteriol. 1977 Mar;129(3):1476–1486. doi: 10.1128/jb.129.3.1476-1486.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
