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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1997 Jul;63(1):74–82. doi: 10.1136/jnnp.63.1.74

Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment

R Elliott 1, B Sahakian 1, J Herrod 1, T Robbins 1, E Paykel 1
PMCID: PMC2169625  PMID: 9221971

Abstract

OBJECTIVES—To assess in further detail the specific form of motivational impairment influencing neuropsychological performance in depression—oversensitivity to perceived failure. The present study considers two questions: firstly whether this is specific to depression and secondly how the effect relates to clinical features.
METHODS—Unipolar depressed patients and matched controls were assessed on two neuropsychological tests giving explicit performance feedback. The data were analysed in two separate studies to consider the questions above. The first study considered the specificity of the effect to depressed patients, using data on the same tests collected from other patient groups. The second study was a longitudinal assessment of the depressed patients on clinical recovery to determine whether the effect is specific to the depressed state.
RESULTS—The effect was not seen in non-depressed patient groups, either neurological or psychiatric groups. The longitudinal study showed a residual abnormal response to negative feedback on clinical recovery.
CONCLUSIONS—Abnormal response to negative feedback is specific to a primary diagnosis of depression and may be a trait rather than a state factor of the disorder. These results are discussed in relation to the putative neuropathology of depression and also to cognitive and behavioural accounts of the disorder. The findings presented here have important implications for establishing a link between mood and cognition in unipolar depression.



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Selected References

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  1. Austin M. P., Ross M., Murray C., O'Carroll R. E., Ebmeier K. P., Goodwin G. M. Cognitive function in major depression. J Affect Disord. 1992 May;25(1):21–29. doi: 10.1016/0165-0327(92)90089-o. [DOI] [PubMed] [Google Scholar]
  2. Baker S. C., Rogers R. D., Owen A. M., Frith C. D., Dolan R. J., Frackowiak R. S., Robbins T. W. Neural systems engaged by planning: a PET study of the Tower of London task. Neuropsychologia. 1996 Jun;34(6):515–526. doi: 10.1016/0028-3932(95)00133-6. [DOI] [PubMed] [Google Scholar]
  3. Beats B. C., Sahakian B. J., Levy R. Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med. 1996 May;26(3):591–603. doi: 10.1017/s0033291700035662. [DOI] [PubMed] [Google Scholar]
  4. Crow T. J. Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schizophr Bull. 1990;16(3):433–443. doi: 10.1093/schbul/16.3.433. [DOI] [PubMed] [Google Scholar]
  5. Cummings J. L. Subcortical dementia. Neuropsychology, neuropsychiatry, and pathophysiology. Br J Psychiatry. 1986 Dec;149:682–697. doi: 10.1192/bjp.149.6.682. [DOI] [PubMed] [Google Scholar]
  6. Drevets W. C., Videen T. O., Price J. L., Preskorn S. H., Carmichael S. T., Raichle M. E. A functional anatomical study of unipolar depression. J Neurosci. 1992 Sep;12(9):3628–3641. doi: 10.1523/JNEUROSCI.12-09-03628.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Elliott R., Sahakian B. J., McKay A. P., Herrod J. J., Robbins T. W., Paykel E. S. Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance. Psychol Med. 1996 Sep;26(5):975–989. doi: 10.1017/s0033291700035303. [DOI] [PubMed] [Google Scholar]
  8. HAMILTON M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960 Feb;23:56–62. doi: 10.1136/jnnp.23.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hughes J. R., Pleasants C. N., Pickens R. W. Measurement of reinforcement in depression: a pilot study. J Behav Ther Exp Psychiatry. 1985 Sep;16(3):231–236. doi: 10.1016/0005-7916(85)90068-0. [DOI] [PubMed] [Google Scholar]
  10. Miller W. R. Psychological deficit in depression. Psychol Bull. 1975 Mar;82(2):238–260. doi: 10.1037/h0076367. [DOI] [PubMed] [Google Scholar]
  11. Montgomery S. A., Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979 Apr;134:382–389. doi: 10.1192/bjp.134.4.382. [DOI] [PubMed] [Google Scholar]
  12. Owen A. M., Downes J. J., Sahakian B. J., Polkey C. E., Robbins T. W. Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia. 1990;28(10):1021–1034. doi: 10.1016/0028-3932(90)90137-d. [DOI] [PubMed] [Google Scholar]
  13. Owen A. M., Roberts A. C., Hodges J. R., Summers B. A., Polkey C. E., Robbins T. W. Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease. Brain. 1993 Oct;116(Pt 5):1159–1175. doi: 10.1093/brain/116.5.1159. [DOI] [PubMed] [Google Scholar]
  14. Owen A. M., Sahakian B. J., Semple J., Polkey C. E., Robbins T. W. Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologia. 1995 Jan;33(1):1–24. doi: 10.1016/0028-3932(94)00098-a. [DOI] [PubMed] [Google Scholar]
  15. Richards P. M., Ruff R. M. Motivational effects on neuropsychological functioning: comparison of depressed versus nondepressed individuals. J Consult Clin Psychol. 1989 Jun;57(3):396–402. doi: 10.1037//0022-006x.57.3.396. [DOI] [PubMed] [Google Scholar]
  16. Robbins T. W., James M., Lange K. W., Owen A. M., Quinn N. P., Marsden C. D. Cognitive performance in multiple system atrophy. Brain. 1992 Feb;115(Pt 1):271–291. doi: 10.1093/brain/115.1.271. [DOI] [PubMed] [Google Scholar]
  17. Robbins T. W., James M., Owen A. M., Sahakian B. J., McInnes L., Rabbitt P. Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia. 1994 Sep-Oct;5(5):266–281. doi: 10.1159/000106735. [DOI] [PubMed] [Google Scholar]
  18. Robbins T. W. The case of frontostriatal dysfunction in schizophrenia. Schizophr Bull. 1990;16(3):391–402. doi: 10.1093/schbul/16.3.391. [DOI] [PubMed] [Google Scholar]
  19. Rogers D., Lees A. J., Smith E., Trimble M., Stern G. M. Bradyphrenia in Parkinson's disease and psychomotor retardation in depressive illness. An experimental study. Brain. 1987 Jun;110(Pt 3):761–776. doi: 10.1093/brain/110.3.761. [DOI] [PubMed] [Google Scholar]
  20. Sahakian B. J., Morris R. G., Evenden J. L., Heald A., Levy R., Philpot M., Robbins T. W. A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain. 1988 Jun;111(Pt 3):695–718. doi: 10.1093/brain/111.3.695. [DOI] [PubMed] [Google Scholar]
  21. Schmand B., Kuipers T., Van der Gaag M., Bosveld J., Bulthuis F., Jellema M. Cognitive disorders and negative symptoms as correlates of motivational deficits in psychotic patients. Psychol Med. 1994 Nov;24(4):869–884. doi: 10.1017/s0033291700028968. [DOI] [PubMed] [Google Scholar]
  22. Starkstein S. E., Preziosi T. J., Berthier M. L., Bolduc P. L., Mayberg H. S., Robinson R. G. Depression and cognitive impairment in Parkinson's disease. Brain. 1989 Oct;112(Pt 5):1141–1153. doi: 10.1093/brain/112.5.1141. [DOI] [PubMed] [Google Scholar]
  23. Taylor A. E., Saint-Cyr J. A., Lang A. E., Kenny F. T. Parkinson's disease and depression. A critical re-evaluation. Brain. 1986 Apr;109(Pt 2):279–292. doi: 10.1093/brain/109.2.279. [DOI] [PubMed] [Google Scholar]
  24. Teasdale J. D., Dent J. Cognitive vulnerability to depression: an investigation of two hypotheses. Br J Clin Psychol. 1987 May;26(Pt 2):113–126. doi: 10.1111/j.2044-8260.1987.tb00737.x. [DOI] [PubMed] [Google Scholar]
  25. Vaughn C. E., Leff J. P. The influence of family and social factors on the course of psychiatric illness. A comparison of schizophrenic and depressed neurotic patients. Br J Psychiatry. 1976 Aug;129:125–137. doi: 10.1192/bjp.129.2.125. [DOI] [PubMed] [Google Scholar]
  26. Weingartner H., Cohen R. M., Murphy D. L., Martello J., Gerdt C. Cognitive processes in depression. Arch Gen Psychiatry. 1981 Jan;38(1):42–47. doi: 10.1001/archpsyc.1981.01780260044004. [DOI] [PubMed] [Google Scholar]
  27. Wener A. E., Rehm L. P. Depressive affect: a test of behavioral hypotheses. J Abnorm Psychol. 1975 Jun;84(3):221–227. doi: 10.1037/h0076725. [DOI] [PubMed] [Google Scholar]
  28. Zubenko G. S., Moossy J., Kopp U. Neurochemical correlates of major depression in primary dementia. Arch Neurol. 1990 Feb;47(2):209–214. doi: 10.1001/archneur.1990.00530020117023. [DOI] [PubMed] [Google Scholar]

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