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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1998 Sep;65(3):344–347. doi: 10.1136/jnnp.65.3.344

Dopaminergic stimulation in unilateral neglect

G Geminiani 1, G Bottini 1, R Sterzi 1
PMCID: PMC2170229  PMID: 9728946

Abstract

OBJECTIVE—To explore the hypothesis that dopaminergic circuits play a part in the premotor components of the unilateral neglect syndrome, the effects of acute dopaminergic stimulation in patients with neglect were studied.
METHODS—Two tasks were evaluated before and after subcutaneous administration of apomorphine and placebo: a circle crossing test and a test of target exploration (a modified version of the bell test), performed both in perceptual (counting) and in perceptual-motor (pointing) conditions.
SUBJECTS—Four patients with left neglect.
RESULTS—After dopaminergic stimulation, a significant improvement was found compared with placebo administration and baseline evaluation, in the performance of the two tests. Three of the patients had a more marked improvement in the perceptual-motor condition (pointing) of the task than the perceptual condition (counting).
CONCLUSIONS—The findings suggest that dopaminergic neuronal networks may mediate, in different ways, both perceptive and premotor components of the unilateral neglect syndrome. 



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Selected References

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  1. Annett L. E., Rogers D. C., Hernandez T. D., Dunnett S. B. Behavioural analysis of unilateral monoamine depletion in the marmoset. Brain. 1992 Jun;115(Pt 3):825–856. doi: 10.1093/brain/115.3.825. [DOI] [PubMed] [Google Scholar]
  2. Bisiach E., Geminiani G., Berti A., Rusconi M. L. Perceptual and premotor factors of unilateral neglect. Neurology. 1990 Aug;40(8):1278–1281. doi: 10.1212/wnl.40.8.1278. [DOI] [PubMed] [Google Scholar]
  3. Bottini G., Sterzi R., Vallar G. Directional hypokinesia in spatial hemineglect: a case study. J Neurol Neurosurg Psychiatry. 1992 Jul;55(7):562–565. doi: 10.1136/jnnp.55.7.562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown R. M., Crane A. M., Goldman P. S. Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates. Brain Res. 1979 May 18;168(1):133–150. doi: 10.1016/0006-8993(79)90132-x. [DOI] [PubMed] [Google Scholar]
  5. Carli M., Evenden J. L., Robbins T. W. Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention. Nature. 1985 Feb 21;313(6004):679–682. doi: 10.1038/313679a0. [DOI] [PubMed] [Google Scholar]
  6. Corwin J. V., Kanter S., Watson R. T., Heilman K. M., Valenstein E., Hashimoto A. Apomorphine has a therapeutic effect on neglect produced by unilateral dorsomedial prefrontal cortex lesions in rats. Exp Neurol. 1986 Dec;94(3):683–698. doi: 10.1016/0014-4886(86)90247-5. [DOI] [PubMed] [Google Scholar]
  7. Coslett H. B., Bowers D., Fitzpatrick E., Haws B., Heilman K. M. Directional hypokinesia and hemispatial inattention in neglect. Brain. 1990 Apr;113(Pt 2):475–486. doi: 10.1093/brain/113.2.475. [DOI] [PubMed] [Google Scholar]
  8. Fleet W. S., Valenstein E., Watson R. T., Heilman K. M. Dopamine agonist therapy for neglect in humans. Neurology. 1987 Nov;37(11):1765–1770. doi: 10.1212/wnl.37.11.1765. [DOI] [PubMed] [Google Scholar]
  9. Geminiani G., Bottini G. Mental representation and temporary recovery from unilateral neglect after vestibular stimulation. J Neurol Neurosurg Psychiatry. 1992 Apr;55(4):332–333. doi: 10.1136/jnnp.55.4.332-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Horvath T. B., Meares R. A. L-dopa and arousal. J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):416–420. doi: 10.1136/jnnp.37.4.416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. King V., Corwin J. V. Neglect following unilateral ablation of the caudal but not the rostral portion of medial agranular cortex of the rat and the therapeutic effect of apomorphine. Behav Brain Res. 1990 Mar 5;37(2):169–184. doi: 10.1016/0166-4328(90)90092-s. [DOI] [PubMed] [Google Scholar]
  12. Ljungberg T., Ungerstedt U. Sensory inattention produced by 6-hydroxydopamine-induced degeneration of ascending dopamine neurons in the brain. Exp Neurol. 1976 Dec;53(3):585–600. doi: 10.1016/0014-4886(76)90140-0. [DOI] [PubMed] [Google Scholar]
  13. Marshall J. F., Gotthelf T. Sensory inattention in rats with 6-hydroxydopamine-induced degeneration of ascending dopaminergic neurons: apomorphine-induced reversal of deficits. Exp Neurol. 1979 Aug;65(2):398–411. doi: 10.1016/0014-4886(79)90107-9. [DOI] [PubMed] [Google Scholar]
  14. Miyashita N., Hikosaka O., Kato M. Visual hemineglect induced by unilateral striatal dopamine deficiency in monkeys. Neuroreport. 1995 Jun 19;6(9):1257–1260. doi: 10.1097/00001756-199506090-00007. [DOI] [PubMed] [Google Scholar]
  15. Ross E. D., Stewart R. M. Akinetic mutism from hypothalamic damage: successful treatment with dopamine agonists. Neurology. 1981 Nov;31(11):1435–1439. doi: 10.1212/wnl.31.11.1435. [DOI] [PubMed] [Google Scholar]
  16. Růzicka E., Roth J., Spacková N., Mecír P., Jech R. Apomorphine induced cognitive changes in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994 Aug;57(8):998–1001. doi: 10.1136/jnnp.57.8.998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stibe C. M., Lees A. J., Kempster P. A., Stern G. M. Subcutaneous apomorphine in parkinsonian on-off oscillations. Lancet. 1988 Feb 20;1(8582):403–406. doi: 10.1016/s0140-6736(88)91193-2. [DOI] [PubMed] [Google Scholar]
  18. Vallar G., Rusconi M. L., Geminiani G., Berti A., Cappa S. F. Visual and nonvisual neglect after unilateral brain lesions: modulation by visual input. Int J Neurosci. 1991 Dec;61(3-4):229–239. doi: 10.3109/00207459108990740. [DOI] [PubMed] [Google Scholar]
  19. Watson R. T., Heilman K. M., Miller B. D., King F. A. Neglect after mesencephalic reticular formation lesions. Neurology. 1974 Mar;24(3):294–298. doi: 10.1212/wnl.24.3.294. [DOI] [PubMed] [Google Scholar]

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