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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1998 Sep;65(3):380–381. doi: 10.1136/jnnp.65.3.380

Upbeat nystagmus: clinicoanatomical correlation

J Janssen 1, A Larner 1, H Morris 1, A Bronstein 1, S Farmer 1
PMCID: PMC2170236  PMID: 9728956

Abstract

A patient is reported on with isolated upbeating nystagmus with a linear slow phase in whom a solitary lesion, probably inflammatory, was detected radiologically in the dorsal paramedian caudal medulla, encompassing the most caudal of the perihypoglossal nuclei, the nucleus intercalatus of Staderini. The conjunction of a vestibular pattern of nystagmus with this focal lesion runs contrary to a previous suggestion that the nucleus intercalatus may act as a neural integrator for vertical conjugate eye movements.



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