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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1998 Nov;65(5):641–647. doi: 10.1136/jnnp.65.5.641

Medial temporal lobe atrophy in stroke patients: relation to pre-existing dementia

H Henon 1, F Pasquier 1, I Durieu 1, J Pruvo 1, D Leys 1
PMCID: PMC2170331  PMID: 9810931

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Selected References

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  1. Adams H. P., Jr, Bendixen B. H., Kappelle L. J., Biller J., Love B. B., Gordon D. L., Marsh E. E., 3rd Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993 Jan;24(1):35–41. doi: 10.1161/01.str.24.1.35. [DOI] [PubMed] [Google Scholar]
  2. Blennow K., Wallin A., Uhlemann C., Gottfries C. G. White-matter lesions on CT in Alzheimer patients: relation to clinical symptomatology and vascular factors. Acta Neurol Scand. 1991 Mar;83(3):187–193. doi: 10.1111/j.1600-0404.1991.tb04675.x. [DOI] [PubMed] [Google Scholar]
  3. Bowers J., Jorm A. F., Henderson S., Harris P. General practitioners' detection of depression and dementia in elderly patients. Med J Aust. 1990 Aug 20;153(4):192–196. doi: 10.5694/j.1326-5377.1990.tb136858.x. [DOI] [PubMed] [Google Scholar]
  4. Charletta D., Gorelick P. B., Dollear T. J., Freels S., Harris Y. CT and MRI findings among African-Americans with Alzheimer's disease, vascular dementia, and stroke without dementia. Neurology. 1995 Aug;45(8):1456–1461. doi: 10.1212/wnl.45.8.1456. [DOI] [PubMed] [Google Scholar]
  5. Convit A., de Leon M. J., Hoptman M. J., Tarshish C., De Santi S., Rusinek H. Age-related changes in brain: I. Magnetic resonance imaging measures of temporal lobe volumes in normal subjects. Psychiatr Q. 1995 Winter;66(4):343–355. doi: 10.1007/BF02238754. [DOI] [PubMed] [Google Scholar]
  6. Copeland J. R., Kelleher M. J., Kellett J. M., Gourlay A. J., Gurland B. J., Fleiss J. L., Sharpe L. A semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: the Geriatric Mental State Schedule. I. Development and reliability. Psychol Med. 1976 Aug;6(3):439–449. doi: 10.1017/s0033291700015889. [DOI] [PubMed] [Google Scholar]
  7. Davis P. B., White H., Price J. L., McKeel D., Robins L. N. Retrospective postmortem dementia assessment. Validation of a new clinical interview to assist neuropathologic study. Arch Neurol. 1991 Jun;48(6):613–617. doi: 10.1001/archneur.1991.00530180069019. [DOI] [PubMed] [Google Scholar]
  8. DeCarli C., Murphy D. G., Gillette J. A., Haxby J. V., Teichberg D., Schapiro M. B., Horwitz B. Lack of age-related differences in temporal lobe volume of very healthy adults. AJNR Am J Neuroradiol. 1994 Apr;15(4):689–696. [PMC free article] [PubMed] [Google Scholar]
  9. Del-Ser T., Morales J. M., Barquero M. S., Cantón R., Bermejo F. Application of a Spanish version of the "Informant Questionnaire on Cognitive Decline in the Elderly" in the clinical assessment of dementia. Alzheimer Dis Assoc Disord. 1997 Mar;11(1):3–8. doi: 10.1097/00002093-199703000-00002. [DOI] [PubMed] [Google Scholar]
  10. Double K. L., Halliday G. M., Kril J. J., Harasty J. A., Cullen K., Brooks W. S., Creasey H., Broe G. A. Topography of brain atrophy during normal aging and Alzheimer's disease. Neurobiol Aging. 1996 Jul-Aug;17(4):513–521. doi: 10.1016/0197-4580(96)00005-x. [DOI] [PubMed] [Google Scholar]
  11. Folstein M. F., Folstein S. E., McHugh P. R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6. [DOI] [PubMed] [Google Scholar]
  12. Frisoni G. B., Bianchetti A., Geroldi C., Trabucchi M., Beltramello A., Weiss C. Measures of medial temporal lobe atrophy in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1438–1439. doi: 10.1136/jnnp.57.11.1438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Frisoni G. B., Geroldi C., Bianchetti A., Trabucchi M., Govoni S., Franceschini G., Calabresi L. Apolipoprotein E epsilon 4 allele frequency in vascular dementia and Alzheimer's disease. Stroke. 1994 Aug;25(8):1703–1704. doi: 10.1161/01.str.25.8.1703. [DOI] [PubMed] [Google Scholar]
  14. George A. E., de Leon M. J., Stylopoulos L. A., Miller J., Kluger A., Smith G., Miller D. C. CT diagnostic features of Alzheimer disease: importance of the choroidal/hippocampal fissure complex. AJNR Am J Neuroradiol. 1990 Jan-Feb;11(1):101–107. [PMC free article] [PubMed] [Google Scholar]
  15. Golomb J., de Leon M. J., Kluger A., George A. E., Tarshish C., Ferris S. H. Hippocampal atrophy in normal aging. An association with recent memory impairment. Arch Neurol. 1993 Sep;50(9):967–973. doi: 10.1001/archneur.1993.00540090066012. [DOI] [PubMed] [Google Scholar]
  16. Greenwald B. S., Kramer-Ginsberg E., Bogerts B., Ashtari M., Aupperle P., Wu H., Allen L., Zeman D., Patel M. Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer's disease? Psychol Med. 1997 Mar;27(2):421–431. doi: 10.1017/s0033291796004576. [DOI] [PubMed] [Google Scholar]
  17. Huppert F. A., Tym E. Clinical and neuropsychological assessment of dementia. Br Med Bull. 1986 Jan;42(1):11–18. doi: 10.1093/oxfordjournals.bmb.a072089. [DOI] [PubMed] [Google Scholar]
  18. Hénon H., Durieu I., Lucas C., Godefroy O., Pasquier F., Leys D. Dementia in stroke. Neurology. 1996 Sep;47(3):852–853. doi: 10.1212/wnl.47.3.852-a. [DOI] [PubMed] [Google Scholar]
  19. Ince P. G., McArthur F. K., Bjertness E., Torvik A., Candy J. M., Edwardson J. A. Neuropathological diagnoses in elderly patients in Oslo: Alzheimer's disease, Lewy body disease, vascular lesions. Dementia. 1995 May-Jun;6(3):162–168. doi: 10.1159/000106940. [DOI] [PubMed] [Google Scholar]
  20. Inzitari D., Giordano G. P., Ancona A. L., Pracucci G., Mascalchi M., Amaducci L. Leukoaraiosis, intracerebral hemorrhage, and arterial hypertension. Stroke. 1990 Oct;21(10):1419–1423. doi: 10.1161/01.str.21.10.1419. [DOI] [PubMed] [Google Scholar]
  21. Jellinger K., Danielczyk W., Fischer P., Gabriel E. Clinicopathological analysis of dementia disorders in the elderly. J Neurol Sci. 1990 Mar;95(3):239–258. doi: 10.1016/0022-510x(90)90072-u. [DOI] [PubMed] [Google Scholar]
  22. Jobst K. A., Smith A. D., Szatmari M., Molyneux A., Esiri M. E., King E., Smith A., Jaskowski A., McDonald B., Wald N. Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet. 1992 Nov 14;340(8829):1179–1183. doi: 10.1016/0140-6736(92)92890-r. [DOI] [PubMed] [Google Scholar]
  23. Jorm A. F., Jacomb P. A. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med. 1989 Nov;19(4):1015–1022. doi: 10.1017/s0033291700005742. [DOI] [PubMed] [Google Scholar]
  24. Jorm A. F., Korten A. E. Assessment of cognitive decline in the elderly by informant interview. Br J Psychiatry. 1988 Feb;152:209–213. doi: 10.1192/bjp.152.2.209. [DOI] [PubMed] [Google Scholar]
  25. Jorm A. F. Methods of screening for dementia: a meta-analysis of studies comparing an informant questionnaire with a brief cognitive test. Alzheimer Dis Assoc Disord. 1997 Sep;11(3):158–162. [PubMed] [Google Scholar]
  26. Jorm A. F., Scott R., Cullen J. S., MacKinnon A. J. Performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening test for dementia. Psychol Med. 1991 Aug;21(3):785–790. doi: 10.1017/s0033291700022418. [DOI] [PubMed] [Google Scholar]
  27. Kaye J. A., Swihart T., Howieson D., Dame A., Moore M. M., Karnos T., Camicioli R., Ball M., Oken B., Sexton G. Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology. 1997 May;48(5):1297–1304. doi: 10.1212/wnl.48.5.1297. [DOI] [PubMed] [Google Scholar]
  28. Killiany R. J., Moss M. B., Albert M. S., Sandor T., Tieman J., Jolesz F. Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease. Arch Neurol. 1993 Sep;50(9):949–954. doi: 10.1001/archneur.1993.00540090052010. [DOI] [PubMed] [Google Scholar]
  29. Kokmen E., Whisnant J. P., O'Fallon W. M., Chu C. P., Beard C. M. Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984) Neurology. 1996 Jan;46(1):154–159. doi: 10.1212/wnl.46.1.154. [DOI] [PubMed] [Google Scholar]
  30. Laakso M. P., Partanen K., Riekkinen P., Lehtovirta M., Helkala E. L., Hallikainen M., Hanninen T., Vainio P., Soininen H. Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study. Neurology. 1996 Mar;46(3):678–681. doi: 10.1212/wnl.46.3.678. [DOI] [PubMed] [Google Scholar]
  31. Launer L. J., Scheltens P., Lindeboom J., Barkhof F., Weinstein H. C., Jonker C. Medial temporal lobe atrophy in an open population of very old persons: cognitive, brain atrophy, and sociomedical correlates. Neurology. 1995 Apr;45(4):747–752. doi: 10.1212/wnl.45.4.747. [DOI] [PubMed] [Google Scholar]
  32. Law S., Wolfson C. Validation of a French version of an informant-based questionnaire as a screening test for Alzheimer's disease. Br J Psychiatry. 1995 Oct;167(4):541–544. doi: 10.1192/bjp.167.4.541. [DOI] [PubMed] [Google Scholar]
  33. Leys D., Pruvo J. P., Petit H., Gaudet Y., Clarisse J. Maladie d'Alzheimer. Analyse statistique des résultats du scanner X. Rev Neurol (Paris) 1989;145(2):134–139. [PubMed] [Google Scholar]
  34. Loeb C., Gandolfo C., Croce R., Conti M. Dementia associated with lacunar infarction. Stroke. 1992 Sep;23(9):1225–1229. doi: 10.1161/01.str.23.9.1225. [DOI] [PubMed] [Google Scholar]
  35. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. doi: 10.1212/wnl.34.7.939. [DOI] [PubMed] [Google Scholar]
  36. Morales J. M., Gonzalez-Montalvo J. I., Bermejo F., Del-Ser T. The screening of mild dementia with a shortened Spanish version of the "Informant Questionnaire on Cognitive Decline in the Elderly". Alzheimer Dis Assoc Disord. 1995 Summer;9(2):105–111. doi: 10.1097/00002093-199509020-00008. [DOI] [PubMed] [Google Scholar]
  37. Morris J. C., Fulling K. Early Alzheimer's disease. Diagnostic considerations. Arch Neurol. 1988 Mar;45(3):345–349. doi: 10.1001/archneur.1988.00520270127033. [DOI] [PubMed] [Google Scholar]
  38. Mounier-Vehier F., Leys D., Rondepierre P., Godefroy O., Pruvo J. P. Silent infarcts in patients with ischemic stroke are related to age and size of the left atrium. Stroke. 1993 Sep;24(9):1347–1351. doi: 10.1161/01.str.24.9.1347. [DOI] [PubMed] [Google Scholar]
  39. Mulligan R., Mackinnon A., Jorm A. F., Giannakopoulos P., Michel J. P. A comparison of alternative methods of screening for dementia in clinical settings. Arch Neurol. 1996 Jun;53(6):532–536. doi: 10.1001/archneur.1996.00550060074019. [DOI] [PubMed] [Google Scholar]
  40. O'Brien J. T., Desmond P., Ames D., Schweitzer I., Tress B. Magnetic resonance imaging correlates of memory impairment in the healthy elderly: association with medial temporal lobe atrophy but not white matter lesions. Int J Geriatr Psychiatry. 1997 Mar;12(3):369–374. [PubMed] [Google Scholar]
  41. Orgogozo J. M., Capildeo R., Anagnostou C. N., Juge O., Péré J. J., Dartigues J. F., Steiner T. J., Yotis A., Rose F. C. Mise au point d'un score neurologique pour l'évaluation clinique des infarctus sylviens. Presse Med. 1983 Dec 29;12(48):3039–3044. [PubMed] [Google Scholar]
  42. Pasquier F., Bail L., Lebert F., Pruvo J. P., Petit H. Determination of medial temporal lobe atrophy in early Alzheimer's disease with computed tomography. Lancet. 1994 Apr 2;343(8901):861–862. doi: 10.1016/s0140-6736(94)92068-0. [DOI] [PubMed] [Google Scholar]
  43. Pasquier F., Hamon M., Lebert F., Jacob B., Pruvo J. P., Petit H. Medial temporal lobe atrophy in memory disorders. J Neurol. 1997 Mar;244(3):175–181. doi: 10.1007/s004150050069. [DOI] [PubMed] [Google Scholar]
  44. Pasquier F., Leys D. Why are stroke patients prone to develop dementia? J Neurol. 1997 Mar;244(3):135–142. doi: 10.1007/s004150050064. [DOI] [PubMed] [Google Scholar]
  45. Saunders A. M., Roses A. D. Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease. Stroke. 1993 Sep;24(9):1416–1417. doi: 10.1161/01.str.24.9.1416. [DOI] [PubMed] [Google Scholar]
  46. Scheltens P., Leys D., Barkhof F., Huglo D., Weinstein H. C., Vermersch P., Kuiper M., Steinling M., Wolters E. C., Valk J. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):967–972. doi: 10.1136/jnnp.55.10.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Tatemichi T. K., Desmond D. W., Mayeux R., Paik M., Stern Y., Sano M., Remien R. H., Williams J. B., Mohr J. P., Hauser W. A. Dementia after stroke: baseline frequency, risks, and clinical features in a hospitalized cohort. Neurology. 1992 Jun;42(6):1185–1193. doi: 10.1212/wnl.42.6.1185. [DOI] [PubMed] [Google Scholar]
  48. Tatemichi T. K., Foulkes M. A., Mohr J. P., Hewitt J. R., Hier D. B., Price T. R., Wolf P. A. Dementia in stroke survivors in the Stroke Data Bank cohort. Prevalence, incidence, risk factors, and computed tomographic findings. Stroke. 1990 Jun;21(6):858–866. doi: 10.1161/01.str.21.6.858. [DOI] [PubMed] [Google Scholar]
  49. Tatemichi T. K. How acute brain failure becomes chronic: a view of the mechanisms of dementia related to stroke. Neurology. 1990 Nov;40(11):1652–1659. doi: 10.1212/wnl.40.11.1652. [DOI] [PubMed] [Google Scholar]
  50. Tatemichi T. K., Paik M., Bagiella E., Desmond D. W., Stern Y., Sano M., Hauser W. A., Mayeux R. Risk of dementia after stroke in a hospitalized cohort: results of a longitudinal study. Neurology. 1994 Oct;44(10):1885–1891. doi: 10.1212/wnl.44.10.1885. [DOI] [PubMed] [Google Scholar]
  51. Terry J. G., Howard G., Mercuri M., Bond M. G., Crouse J. R., 3rd Apolipoprotein E polymorphism is associated with segment-specific extracranial carotid artery intima-media thickening. Stroke. 1996 Oct;27(10):1755–1759. doi: 10.1161/01.str.27.10.1755. [DOI] [PubMed] [Google Scholar]
  52. Victoroff J., Mack W. J., Lyness S. A., Chui H. C. Multicenter clinicopathological correlation in dementia. Am J Psychiatry. 1995 Oct;152(10):1476–1484. doi: 10.1176/ajp.152.10.1476. [DOI] [PubMed] [Google Scholar]
  53. Willmer J., Carruthers A., Guzman D. A., Collins B., Pogue J., Stuss D. T. The usefulness of CT scanning in diagnosing dementia of the Alzheimer type. Can J Neurol Sci. 1993 Aug;20(3):210–216. doi: 10.1017/s0317167100047958. [DOI] [PubMed] [Google Scholar]
  54. de Leon M. J., George A. E., Stylopoulos L. A., Smith G., Miller D. C. Early marker for Alzheimer's disease: the atrophic hippocampus. Lancet. 1989 Sep 16;2(8664):672–673. doi: 10.1016/s0140-6736(89)90911-2. [DOI] [PubMed] [Google Scholar]
  55. de Leon M. J., Golomb J., George A. E., Convit A., Tarshish C. Y., McRae T., De Santi S., Smith G., Ferris S. H., Noz M. The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. AJNR Am J Neuroradiol. 1993 Jul-Aug;14(4):897–906. [PMC free article] [PubMed] [Google Scholar]

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