Abstract
The incorporation of [3H]thymidine into deoxyribonucleic acid by exponentially growing cells of Bacillus brevis was inhibited by streptolydigin and rifampin in the same concentration range in which these drugs inhibit ribonucleic acid synthesis. Complete inhibition occurred within one-third generation time after drug addition, suggesting an effect on deoxyribonucleic acid chain elongation.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bouché J. P., Zechel K., Kornberg A. dnaG gene product, a rifampicin-resistant RNA polymerase, initiates the conversion of a single-stranded coliphage DNA to its duplex replicative form. J Biol Chem. 1975 Aug 10;250(15):5995–6001. [PubMed] [Google Scholar]
- Brutlag D., Schekman R., Kornberg A. A possible role for RNA polymerase in the initiation of M13 DNA synthesis. Proc Natl Acad Sci U S A. 1971 Nov;68(11):2826–2829. doi: 10.1073/pnas.68.11.2826. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cozzarelli N. R. DNA gyrase and the supercoiling of DNA. Science. 1980 Feb 29;207(4434):953–960. doi: 10.1126/science.6243420. [DOI] [PubMed] [Google Scholar]
- Lark K. G. Evidence for the direct involvement of RNA in the initiation of DNA replication in Escherichia coli 15T. J Mol Biol. 1972 Feb 28;64(1):47–60. doi: 10.1016/0022-2836(72)90320-8. [DOI] [PubMed] [Google Scholar]
- Lark K. G. Genetic control over the initiation of the synthesis of the short deoxynucleotide chains in E. coli. Nat New Biol. 1972 Dec 20;240(103):237–240. doi: 10.1038/newbio240237a0. [DOI] [PubMed] [Google Scholar]
- Laurent S. J. Initiation of deoxyribonucleic acid replication in a temperature-sensitive mutant of B. subtilis: evidence for a transcriptional step. J Bacteriol. 1973 Oct;116(1):141–145. doi: 10.1128/jb.116.1.141-145.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mackenzie J. M., Neville M. M., Wright G. E., Brown N. C. Hydroxyphenylazopyrimidines: characterization of the active forms and their inhibitory action on a DNA polymerase from Bacillus subtilis. Proc Natl Acad Sci U S A. 1973 Feb;70(2):512–516. doi: 10.1073/pnas.70.2.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ogawa T., Okazaki T. Discontinuous DNA replication. Annu Rev Biochem. 1980;49:421–457. doi: 10.1146/annurev.bi.49.070180.002225. [DOI] [PubMed] [Google Scholar]
- Okazaki R., Okazaki T., Sakabe K., Sugimoto K., Sugino A. Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains. Proc Natl Acad Sci U S A. 1968 Feb;59(2):598–605. doi: 10.1073/pnas.59.2.598. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sarkar N. Involvement of RNA polymerase in the synthesis of DNA by growing and toluene-treated cells of Bacillus brevis. Biochem Biophys Res Commun. 1975 Jan 20;62(2):212–219. doi: 10.1016/s0006-291x(75)80125-2. [DOI] [PubMed] [Google Scholar]
- Sarkar N., Paulus H. A guanosine 3':5'-monophosphate-sensitive nuclease from Bacillus brevis. J Biol Chem. 1975 Jan 25;250(2):684–690. [PubMed] [Google Scholar]
- Sarkar N., Paulus H. Function of peptide antibiotics in sporulation. Nat New Biol. 1972 Oct 25;239(95):228–230. doi: 10.1038/newbio239228a0. [DOI] [PubMed] [Google Scholar]
- Sonenshein A. L., Alexander H. B. Initiation of transcription in vitro inhibited by lipiarmycin. J Mol Biol. 1979 Jan 5;127(1):55–72. doi: 10.1016/0022-2836(79)90459-5. [DOI] [PubMed] [Google Scholar]
