Abstract
The effect of midazolam, a water-soluble benzodiazepine, on the somatosensory evoked potentials (SEPs) following strong electrical stimulation of the upper lip, was investigated in Wistar albino rats. SEPs were recorded from the surface of the skull in the contralateral temporal area. A computer was used to obtain the averaged SEPs. The rats received intraperitoneal dosages of 1.25, 2.5, or 5.0 mg/kg of midazolam, or physiological saline. Relative amplitudes of the P1N1 wave were reduced significantly after midazolam injection. Amplitude recovered to the control level about 120 min after the injection in the 1.25 mg/kg group. In 2.5 and 5.0 mg/kg groups, midazolam-induced suppression did not recover within 120 min. No significant differences were found in the latencies of P1 and N1 before and after midazolam injection. It is suggested that midazolam has a mild analgesic effect due to central suppression of the pain perception following noxious stimuli.
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Selected References
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- Kaufman E., Dworkin S. F., LeResche L., Chen A. C., Schubert M. M., Benedetti C. Analgesic action of intravenous diazepam. Anesth Prog. 1984 Mar-Apr;31(2):70–73. [PMC free article] [PubMed] [Google Scholar]
- Sasaki K., Staunton H. P., Dieckmann G. Characteristic features of augmenting and recruiting responses in the cerebral cortex. Exp Neurol. 1970 Feb;26(2):369–392. doi: 10.1016/0014-4886(70)90133-0. [DOI] [PubMed] [Google Scholar]
- Toda K., Ichioka M., Suda H., Iriki A. Effects of electroacupuncture on the somatosensory evoked response in rat. Exp Neurol. 1979 Mar;63(3):652–658. doi: 10.1016/0014-4886(79)90179-1. [DOI] [PubMed] [Google Scholar]
- Toda K., Tanaka H., Iriki A. Effects of diazepam (cercine) on the somatosensory evoked responses following tooth pulp stimulation in rat. Bull Tokyo Med Dent Univ. 1979 Jun;26(2):85–89. [PubMed] [Google Scholar]