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. 1986 Mar-Apr;33(2):87–90.

Cholecystokinin and Pain*

Jay W McRoberts
PMCID: PMC2175459  PMID: 2872841

Abstract

The recent discovery that cholecystokinin (CCK) is present in the nervous system has prompted studies that have nearly proven its neurotransmitter status. Pain modulation appears to be a major effect of CCK and proglumide, its antagonist. CCK's inhibitory effect and proglumide's potentiating effect on opiate analgesia may have clinical application; proglumide's inhibitory effect on opiate tolerance may help in management of chronic pain. More research is required before the CCK/opiate interaction can be exploited on a large scale to relieve pain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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