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British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1993 May;109(1):3–5. doi: 10.1111/j.1476-5381.1993.tb13522.x

Adenosine A3 receptors mediate hypotension in the angiotensin II-supported circulation of the pithed rat.

J R Fozard 1, A M Carruthers 1
PMCID: PMC2175589  PMID: 8495245

Abstract

The cardiovascular effects of N6-2-(4-aminophenyl)ethyladenosine (APNEA), which when radiolabelled with 125I shows high affinity for the newly described adenosine A3 receptor, have been investigated in the angiotensin II-supported circulation of the pithed rat. APNEA induces hypotensive responses which are unaffected by high doses (20-40 mg kg-1) of the broad spectrum, adenosine receptor antagonist, 8-(p-sulphophenyl)theophylline (8-SPT). 8-SPT-resistant falls in blood pressure are also seen, in the absence of bradycardia, with 5'-N-ethylcarboxamidoadenosine (NECA) and the R- and S-enantiomers of N6-phenylisopropyladenosine (PIA). Xanthine insensitivity, high potencies of APNEA, NECA and R-PIA, and an enantiomeric selectivity favouring R- over S-PIA are distinguishing features of the adenosine A3 receptor. We suggest that hypotension in the pithed rat may be a functional correlate of this site.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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