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. 1993 May;109(1):142–147. doi: 10.1111/j.1476-5381.1993.tb13544.x

Modulation by histamine of the delayed outward potassium current in guinea-pig ventricular myocytes.

K Yazawa 1, Y Abiko 1
PMCID: PMC2175605  PMID: 8098639

Abstract

1. Histamine receptor-mediated modulation of the delayed outward potassium current (IK) was investigated in guinea-pig single ventricular cells by the whole-cell voltage clamp. 2. Histamine increased IK in a dose- dependent manner with a half-maximum dose of 3.8 x 10(-8) M. Histamine (10(-6) M) increased IK by a factor of 3.02 without a significant change in the current kinetics. The threshold dose of histamine for increasing IK was 10(-9) M and this value was similar to that for calcium current. 3. Cimetidine decreased IK in the presence of histamine, by shifting the dose-response curve to histamine to the right. The pA2 value of cimetidine against histamine was 6.38. 4. Forskolin did not increase IK after application of 10(-6) M histamine, and histamine scarcely increased IK in the presence of a heat-stable inhibitor of cyclic AMP-dependent protein kinase (PKI). 5. We conclude that stimulation by histamine of IK is mainly by way of the H2-receptor, and is mediated by cyclic AMP-dependent phosphorylation.

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Selected References

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  1. Ahn H. S., Barnett A. Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur J Pharmacol. 1986 Aug 7;127(1-2):153–155. doi: 10.1016/0014-2999(86)90219-0. [DOI] [PubMed] [Google Scholar]
  2. Bahinski A., Nairn A. C., Greengard P., Gadsby D. C. Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature. 1989 Aug 31;340(6236):718–721. doi: 10.1038/340718a0. [DOI] [PubMed] [Google Scholar]
  3. Fabiato A., Fabiato F. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol (Paris) 1979;75(5):463–505. [PubMed] [Google Scholar]
  4. Giles W., Nakajima T., Ono K., Shibata E. F. Modulation of the delayed rectifier K+ current by isoprenaline in bull-frog atrial myocytes. J Physiol. 1989 Aug;415:233–249. doi: 10.1113/jphysiol.1989.sp017720. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hamill O. P., Marty A., Neher E., Sakmann B., Sigworth F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 1981 Aug;391(2):85–100. doi: 10.1007/BF00656997. [DOI] [PubMed] [Google Scholar]
  6. Harvey R. D., Hume J. R. Autonomic regulation of a chloride current in heart. Science. 1989 May 26;244(4907):983–985. doi: 10.1126/science.2543073. [DOI] [PubMed] [Google Scholar]
  7. Hescheler J., Tang M., Jastorff B., Trautwein W. On the mechanism of histamine induced enhancement of the cardiac Ca2+ current. Pflugers Arch. 1987 Sep;410(1-2):23–29. doi: 10.1007/BF00581891. [DOI] [PubMed] [Google Scholar]
  8. Kameyama M., Hofmann F., Trautwein W. On the mechanism of beta-adrenergic regulation of the Ca channel in the guinea-pig heart. Pflugers Arch. 1985 Oct;405(3):285–293. doi: 10.1007/BF00582573. [DOI] [PubMed] [Google Scholar]
  9. Kass R. S., Wiegers S. E. The ionic basis of concentration-related effects of noradrenaline on the action potential of calf cardiac purkinje fibres. J Physiol. 1982 Jan;322:541–558. doi: 10.1113/jphysiol.1982.sp014054. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kondo M., Taniyama K., Tanaka C. Histamine H1-receptors in the guinea-pig urinary bladder. Eur J Pharmacol. 1985 Aug 7;114(1):89–92. doi: 10.1016/0014-2999(85)90526-6. [DOI] [PubMed] [Google Scholar]
  11. Matsuoka S., Ehara T., Noma A. Chloride-sensitive nature of the adrenaline-induced current in guinea-pig cardiac myocytes. J Physiol. 1990 Jun;425:579–598. doi: 10.1113/jphysiol.1990.sp018119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ottosson A., Jansen I., Edvinsson L. Pharmacological characterization of histamine receptors in the human temporal artery. Br J Clin Pharmacol. 1989 Feb;27(2):139–145. doi: 10.1111/j.1365-2125.1989.tb05344.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Schild H. O. pA, a new scale for the measurement of drug antagonism. 1947. Br J Pharmacol. 1997 Feb;120(4 Suppl):29–28. doi: 10.1111/j.1476-5381.1997.tb06773.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tanaka H., Furukawa T., Hayafuji M., Habuchi Y. Modulation of the delayed K+ current by histamine in guinea pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 1991 Nov;344(5):582–588. doi: 10.1007/BF00170656. [DOI] [PubMed] [Google Scholar]
  15. Tayo F. M., Bevan J. A. Pharmacological characterization of histamine receptors in the rabbit renal artery. Eur J Pharmacol. 1986 Feb 11;121(1):129–133. doi: 10.1016/0014-2999(86)90402-4. [DOI] [PubMed] [Google Scholar]
  16. Tohse N., Kameyama M., Irisawa H. Intracellular Ca2+ and protein kinase C modulate K+ current in guinea pig heart cells. Am J Physiol. 1987 Nov;253(5 Pt 2):H1321–H1324. doi: 10.1152/ajpheart.1987.253.5.H1321. [DOI] [PubMed] [Google Scholar]
  17. Tohse N., Kameyama M., Sekiguchi K., Shearman M. S., Kanno M. Protein kinase C activation enhances the delayed rectifier potassium current in guinea-pig heart cells. J Mol Cell Cardiol. 1990 Jun;22(6):725–734. doi: 10.1016/0022-2828(90)91015-y. [DOI] [PubMed] [Google Scholar]
  18. Tsien R. Y., Rink T. J. Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium. Biochim Biophys Acta. 1980 Jul;599(2):623–638. doi: 10.1016/0005-2736(80)90205-9. [DOI] [PubMed] [Google Scholar]
  19. Walsh K. B., Begenisich T. B., Kass R. S. Beta-adrenergic modulation in the heart. Independent regulation of K and Ca channels. Pflugers Arch. 1988 Feb;411(2):232–234. doi: 10.1007/BF00582323. [DOI] [PubMed] [Google Scholar]
  20. Walsh K. B., Kass R. S. Distinct voltage-dependent regulation of a heart-delayed IK by protein kinases A and C. Am J Physiol. 1991 Dec;261(6 Pt 1):C1081–C1090. doi: 10.1152/ajpcell.1991.261.6.C1081. [DOI] [PubMed] [Google Scholar]
  21. Walsh K. B., Kass R. S. Regulation of a heart potassium channel by protein kinase A and C. Science. 1988 Oct 7;242(4875):67–69. doi: 10.1126/science.2845575. [DOI] [PubMed] [Google Scholar]
  22. Wolff A. A., Levi R. Histamine and cardiac arrhythmias. Circ Res. 1986 Jan;58(1):1–16. doi: 10.1161/01.res.58.1.1. [DOI] [PubMed] [Google Scholar]
  23. Yatani A., Brown A. M. Rapid beta-adrenergic modulation of cardiac calcium channel currents by a fast G protein pathway. Science. 1989 Jul 7;245(4913):71–74. doi: 10.1126/science.2544999. [DOI] [PubMed] [Google Scholar]
  24. Yazawa K., Kaibara M., Ohara M., Kameyama M. An improved method for isolating cardiac myocytes useful for patch-clamp studies. Jpn J Physiol. 1990;40(1):157–163. doi: 10.2170/jjphysiol.40.157. [DOI] [PubMed] [Google Scholar]
  25. Yazawa K., Kameyama M. Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea-pig ventricular myocytes. J Physiol. 1990 Feb;421:135–150. doi: 10.1113/jphysiol.1990.sp017937. [DOI] [PMC free article] [PubMed] [Google Scholar]

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