Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1993 May;109(1):207–212. doi: 10.1111/j.1476-5381.1993.tb13555.x

Counteraction of the rapid tolerance to 8-OH-DPAT-induced corticosterone secretion in rats by activation of the GABAA receptor-chloride channel complex.

D Kelder 1, S B Ross 1
PMCID: PMC2175609  PMID: 7684303

Abstract

1. The effect of various classes of compounds on the rapidly developed tolerance to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced corticosterone secretion was examined. 2. Compounds activating the gamma-aminobutyric acidA (GABAA) receptor-chloride complex, i.e. muscimol (3 mg kg-1), diazepam (5 mg kg-1), flunitrazepam (1 mg kg-1), sodium pentobarbitone (10-30 mg kg-1) and chlormethiazole ethane disulphonate (50 mg kg-1) counteracted the development of tolerance when injected before or simultaneously with, but not 15 min after 8-OH-DPAT. 3. At these doses the compounds produced an acute increase in serum corticosterone but had, with the exception of muscimol, no effect on the response to the challenge dose of 8-OH-DPAT 24 h later. Muscimol significantly decreased the response. 4. The GABAA chloride channel antagonist, picrotoxin (1 mg kg-1, s.c.), but not bicuculline (1 mg kg-1, i.p.) potentiated the development of tolerance to 8-OH-DPAT-induced corticosterone secretion. 5. A number of compounds with widely differing pharmacological actions were examined and found to have no effect on the development of tolerance to 8-OH-DPAT-induced corticosterone secretion.

Full text

PDF
207

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ben-Eliyahu S., Marek P., Vaccarino A. L., Mogil J. S., Sternberg W. F., Liebeskind J. C. The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat. Brain Res. 1992 Mar 20;575(2):304–308. doi: 10.1016/0006-8993(92)90094-p. [DOI] [PubMed] [Google Scholar]
  2. Carter C., Rivy J. P., Scatton B. Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor. Eur J Pharmacol. 1989 May 30;164(3):611–612. doi: 10.1016/0014-2999(89)90275-6. [DOI] [PubMed] [Google Scholar]
  3. Cross A. J., Stirling J. M., Robinson T. N., Bowen D. M., Francis P. T., Green A. R. The modulation by chlormethiazole of the GABAA-receptor complex in rat brain. Br J Pharmacol. 1989 Sep;98(1):284–290. doi: 10.1111/j.1476-5381.1989.tb16893.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Curtis D. R., Duggan A. W., Felix D., Johnston G. A. Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat. Brain Res. 1971 Sep 10;32(1):69–96. doi: 10.1016/0006-8993(71)90156-9. [DOI] [PubMed] [Google Scholar]
  5. Godfraind T., Miller R., Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev. 1986 Dec;38(4):321–416. [PubMed] [Google Scholar]
  6. Harrison N. L., Simmonds M. A. Two distinct interactions of barbiturates and chlormethiazole with the GABAA receptor complex in rat cuneate nucleus in vitro. Br J Pharmacol. 1983 Oct;80(2):387–394. doi: 10.1111/j.1476-5381.1983.tb10045.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hill D. R., Bowery N. G. 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain. Nature. 1981 Mar 12;290(5802):149–152. doi: 10.1038/290149a0. [DOI] [PubMed] [Google Scholar]
  8. Hjorth S. Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT. J Neural Transm. 1985;61(1-2):131–135. doi: 10.1007/BF01253058. [DOI] [PubMed] [Google Scholar]
  9. Hutson P. H., Donohoe T. P., Curzon G. Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion. Eur J Pharmacol. 1987 Nov 10;143(2):221–228. doi: 10.1016/0014-2999(87)90536-x. [DOI] [PubMed] [Google Scholar]
  10. Khanna J. M., Kalant H., Weiner J., Chau A., Shah G. Ketamine retards chronic but not acute tolerance to ethanol. Pharmacol Biochem Behav. 1992 Jun;42(2):347–350. doi: 10.1016/0091-3057(92)90538-q. [DOI] [PubMed] [Google Scholar]
  11. Khanna J. M., Wu P. H., Weiner J., Kalant H. NMDA antagonist inhibits rapid tolerance to ethanol. Brain Res Bull. 1991 Apr;26(4):643–645. doi: 10.1016/0361-9230(91)90109-w. [DOI] [PubMed] [Google Scholar]
  12. Köhler C., Hall H., Ogren S. O., Gawell L. Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochem Pharmacol. 1985 Jul 1;34(13):2251–2259. doi: 10.1016/0006-2952(85)90778-6. [DOI] [PubMed] [Google Scholar]
  13. Lanni C., Becker E. L. Inhibition of neutrophil phospholipase A2 by p-bromophenylacyl bromide, nordihydroguaiaretic acid, 5,8,11,14-eicosatetraynoic acid and quercetin. Int Arch Allergy Appl Immunol. 1985;76(3):214–217. doi: 10.1159/000233694. [DOI] [PubMed] [Google Scholar]
  14. Larsson L. G., Rényi L., Ross S. B., Svensson B., Angeby-Möller K. Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT. Neuropharmacology. 1990 Feb;29(2):85–91. doi: 10.1016/0028-3908(90)90047-u. [DOI] [PubMed] [Google Scholar]
  15. Leysen J. E., Gommeren W., Van Gompel P., Wynants J., Janssen P. F., Laduron P. M. Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist. Mol Pharmacol. 1985 Jun;27(6):600–611. [PubMed] [Google Scholar]
  16. Lindberg U. H., Thorberg S. O., Bengtsson S., Renyi A. L., Ross S. B., Ogren S. O. Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by alpha-amino acid esters of phenethyl alcohols. J Med Chem. 1978 May;21(5):448–456. doi: 10.1021/jm00203a008. [DOI] [PubMed] [Google Scholar]
  17. Moody E. J., Skolnick P. Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex. Eur J Pharmacol. 1989 May 2;164(1):153–158. doi: 10.1016/0014-2999(89)90242-2. [DOI] [PubMed] [Google Scholar]
  18. Olsen R. W. GABA-benzodiazepine-barbiturate receptor interactions. J Neurochem. 1981 Jul;37(1):1–13. doi: 10.1111/j.1471-4159.1981.tb05284.x. [DOI] [PubMed] [Google Scholar]
  19. Palmer R. M., Moncada S. A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun. 1989 Jan 16;158(1):348–352. doi: 10.1016/s0006-291x(89)80219-0. [DOI] [PubMed] [Google Scholar]
  20. Przegaliński E., Budziszewska B., Warchoł-Kania A., Błaszczyńska E. Stimulation of corticosterone secretion by the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. Pharmacol Biochem Behav. 1989 Jun;33(2):329–334. doi: 10.1016/0091-3057(89)90509-1. [DOI] [PubMed] [Google Scholar]
  21. Ross S. B., Rényi L., Kelder D. N-methyl-D-aspartate receptor antagonists counteract the long lasting 5-HT1A receptor-induced attenuation of postsynaptic responses in the rat in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):138–143. doi: 10.1007/BF00165294. [DOI] [PubMed] [Google Scholar]
  22. Ross S. B., Rényi L., Kelder D. N-methyl-D-aspartate receptor antagonists counteract the long lasting 5-HT1A receptor-induced attenuation of postsynaptic responses in the rat in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):138–143. doi: 10.1007/BF00165294. [DOI] [PubMed] [Google Scholar]
  23. Ruffolo R. R., Jr, Shaar C. J. Relative potency of LY141865 at dopamine DA2 and histamine H2 receptors. Eur J Pharmacol. 1983 Sep 2;92(3-4):295–296. doi: 10.1016/0014-2999(83)90302-3. [DOI] [PubMed] [Google Scholar]
  24. Rényi L., Möller K. A., Ensler K., Evenden J. The non-competitive NMDA receptor antagonist (+)MK-801 counteracts the long-lasting attenuation of the hypothermic response induced by acute doses of 8-OH-DPAT in the rat. Neuropharmacology. 1992 Dec;31(12):1265–1268. doi: 10.1016/0028-3908(92)90055-t. [DOI] [PubMed] [Google Scholar]
  25. Study R. E., Barker J. L. Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7180–7184. doi: 10.1073/pnas.78.11.7180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Tricklebank M. D., Forler C., Fozard J. R. The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur J Pharmacol. 1984 Nov 13;106(2):271–282. doi: 10.1016/0014-2999(84)90714-3. [DOI] [PubMed] [Google Scholar]
  27. Turner D. M., Ransom R. W., Yang J. S., Olsen R. W. Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates. J Pharmacol Exp Ther. 1989 Mar;248(3):960–966. [PubMed] [Google Scholar]
  28. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
  29. Walker J. M., Bowen W. D., Walker F. O., Matsumoto R. R., De Costa B., Rice K. C. Sigma receptors: biology and function. Pharmacol Rev. 1990 Dec;42(4):355–402. [PubMed] [Google Scholar]
  30. Watkins J. C., Krogsgaard-Larsen P., Honoré T. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol Sci. 1990 Jan;11(1):25–33. doi: 10.1016/0165-6147(90)90038-a. [DOI] [PubMed] [Google Scholar]
  31. Weiss B. Techniques for measuring the interaction of drugs with calmodulin. Methods Enzymol. 1983;102:171–184. doi: 10.1016/s0076-6879(83)02018-2. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES