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. 1993 Aug;109(4):902–904. doi: 10.1111/j.1476-5381.1993.tb13705.x

Antagonism of the inhibitory action of neuropeptide Y (NPY) in guinea-pig trachea by the C-terminal fragment NPY (2-36).

M Taoudi Benchekroun 1, S St-Pierre 1, A Fournier 1, A Cadieux 1
PMCID: PMC2175732  PMID: 8401942

Abstract

The C-terminal fragment of neuropeptide Y (NPY), NPY(2-36) was used as a means of discriminating between two differently located NPY receptor sites in guinea-pig trachea. Both NPY and NPY(2-36) reduced the maximal relaxation elicited by vasoactive intestinal peptide (VIP). In contrast, the C-terminal fragment did not mimic the inhibitory action of NPY on the noradrenaline-(NA) evoked response. However, pretreatment of the trachea with 30 nM NPY(2-36), 5 min before generating NA and VIP concentration-response curves in the presence of NPY, abolished the inhibitory effect of NPY on NA-elicited response but did not affect the modulatory action of NPY on VIP-induced relaxation. These results suggest that the two differently located NPY receptor sites in guinea-pig trachea are of two distinct subpopulations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Donoso V., Silva M., St-Pierre S., Huidobro-Toro J. P. Neuropeptide Y (NPY), an endogenous presynaptic modulator of adrenergic neurotransmission in the rat vas deferens: structural and functional studies. Peptides. 1988 May-Jun;9(3):545–553. doi: 10.1016/0196-9781(88)90162-3. [DOI] [PubMed] [Google Scholar]
  2. Dumont Y., Martel J. C., Fournier A., St-Pierre S., Quirion R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog Neurobiol. 1992;38(2):125–167. doi: 10.1016/0301-0082(92)90038-g. [DOI] [PubMed] [Google Scholar]
  3. Grundemar L., Grundström N., Johansson I. G., Andersson R. G., Håkanson R. Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways. Br J Pharmacol. 1990 Mar;99(3):473–476. doi: 10.1111/j.1476-5381.1990.tb12952.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jolicoeur F. B., Michaud J. N., Menard D., Fournier A. In vivo structure activity study supports the existence of heterogeneous neuropeptide Y receptors. Brain Res Bull. 1991 Feb;26(2):309–311. doi: 10.1016/0361-9230(91)90243-d. [DOI] [PubMed] [Google Scholar]
  5. Martel J. C., St-Pierre S., Quirion R. Neuropeptide Y receptors in rat brain: autoradiographic localization. Peptides. 1986 Jan-Feb;7(1):55–60. doi: 10.1016/0196-9781(86)90061-6. [DOI] [PubMed] [Google Scholar]
  6. Rioux F., Bachelard H., Martel J. C., St-Pierre S. The vasoconstrictor effect of neuropeptide Y and related peptides in the guinea pig isolated heart. Peptides. 1986 Jan-Feb;7(1):27–31. doi: 10.1016/0196-9781(86)90056-2. [DOI] [PubMed] [Google Scholar]
  7. Stanley B. G., Magdalin W., Seirafi A., Nguyen M. M., Leibowitz S. F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides. 1992 May-Jun;13(3):581–587. doi: 10.1016/0196-9781(92)90093-i. [DOI] [PubMed] [Google Scholar]
  8. Stretton C. D., Belvisi M. G., Barnes P. J. Neuropeptide Y modulates non-adrenergic, non-cholinergic neural bronchoconstriction in vivo and in vitro. Neuropeptides. 1990 Dec;17(4):163–170. doi: 10.1016/0143-4179(90)90031-s. [DOI] [PubMed] [Google Scholar]
  9. T-Benchekroun M., Fournier A., St-Pierre S., Cadieux A. Inhibitory action of neuropeptide Y on agonist-induced responses in isolated guinea pig trachea. Eur J Pharmacol. 1992 Jun 17;216(3):421–428. doi: 10.1016/0014-2999(92)90440-f. [DOI] [PubMed] [Google Scholar]

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