Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1993 Sep;110(1):113–118. doi: 10.1111/j.1476-5381.1993.tb13779.x

The effect of platelet-activating factor on the responsiveness of the human nasal airway.

C E Austin 1, J C Foreman 1
PMCID: PMC2176011  PMID: 8220870

Abstract

1. The effects of inhaled platelet-activating factor (PAF) on responsiveness of the human nasal airway were examined in normal subjects by measuring nasal airway resistance in response to histamine and bradykinin at 2, 6, 24, 48 h and 7 d after PAF administration. Eosinophil cationic protein (ECP) in nasal secretions was also measured. 2. Intranasal aerosol administration of PAF, 30 or 60 micrograms per nostril to normal human subjects induced an increased responsiveness to inhaled histamine, 50 to 400 micrograms and bradykinin, 100 micrograms per nostril at 2, 6 and 24 h following PAF treatment. However the effect was not apparent at 48 h or 7 days after PAF administration. 3. Intranasal administration of lyso-PAF, 60 micrograms by aerosol did not increase the reactivity of the nasal airway in response to histamine, 200 micrograms. 4. There was no difference in the time course of the PAF-induced hyperresponsiveness to histamine or bradykinin. 5. PAF-induced nasal hyperresponsiveness at 2 and 6 h was associated with increases in the ECP concentration of the nasal lavage fluid. 6. Vitamin E pretreatment of subjects resulted in the attenuation of the PAF-induced hyperresponsiveness to histamine, and a decrease in ECP levels of the nasal lavage fluid. 7. The results suggest that in the human nasal airway, PAF induces a non-specific hyperresponsiveness which is accompanied by eosinophil activation in the nasal cavity. Free radical production induced by PAF may contribute to the hyperresponsiveness and the activation of eosinophils.

Full text

PDF
113

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akaike T., Ando M., Oda T., Doi T., Ijiri S., Araki S., Maeda H. Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J Clin Invest. 1990 Mar;85(3):739–745. doi: 10.1172/JCI114499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Andersson M., Andersson P., Venge P., Pipkorn U. Eosinophils and eosinophil cationic protein in nasal lavages in allergen-induced hyperresponsiveness: effects of topical glucocorticosteroid treatment. Allergy. 1989 Jul;44(5):342–348. doi: 10.1111/j.1398-9995.1989.tb00456.x. [DOI] [PubMed] [Google Scholar]
  3. Andersson M., Pipkorn U. The effect of platelet activating factor on nasal hypersensitivity. Eur J Clin Pharmacol. 1988;35(3):231–235. doi: 10.1007/BF00558258. [DOI] [PubMed] [Google Scholar]
  4. Andersson M., von Kogerer B., Andersson P., Pipkorn U. Allergen-induced nasal hyperreactivity appears unrelated to the size of the nasal and dermal immediate allergic reaction. Allergy. 1987 Nov;42(8):631–637. doi: 10.1111/j.1398-9995.1987.tb00395.x. [DOI] [PubMed] [Google Scholar]
  5. Chapman I. D., Boubekeur K., Morley J. Airway eosinophilia and airway hyperreactivity are parallel rather than sequential events in the guinea-pig. Agents Actions Suppl. 1991;34:445–456. [PubMed] [Google Scholar]
  6. Chung K. F., Aizawa H., Leikauf G. D., Ueki I. F., Evans T. W., Nadel J. A. Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. J Pharmacol Exp Ther. 1986 Mar;236(3):580–584. [PubMed] [Google Scholar]
  7. Coyle A. J., Spina D., Page C. P. PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle. Br J Pharmacol. 1990 Sep;101(1):31–38. doi: 10.1111/j.1476-5381.1990.tb12084.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cuss F. M., Dixon C. M., Barnes P. J. Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet. 1986 Jul 26;2(8500):189–192. doi: 10.1016/s0140-6736(86)92489-x. [DOI] [PubMed] [Google Scholar]
  9. Frigas E., Gleich G. J. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol. 1986 Apr;77(4):527–537. doi: 10.1016/0091-6749(86)90341-6. [DOI] [PubMed] [Google Scholar]
  10. Herd C. M., Donigi-Gale D., Shoupe T. S., Page C. P. Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits. Br J Pharmacol. 1992 Dec;107(4):1108–1115. doi: 10.1111/j.1476-5381.1992.tb13415.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hogg J. C. Bronchial mucosal permeability and its relationship to airways hyperreactivity. J Allergy Clin Immunol. 1981 Jun;67(6):421–425. doi: 10.1016/0091-6749(81)90094-4. [DOI] [PubMed] [Google Scholar]
  12. Katsumata U., Miura M., Ichinose M., Kimura K., Takahashi T., Inoue H., Takishima T. Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized cats. Am Rev Respir Dis. 1990 May;141(5 Pt 1):1158–1161. doi: 10.1164/ajrccm/141.5_Pt_1.1158. [DOI] [PubMed] [Google Scholar]
  13. Linder A., Venge P., Deuschl H. Eosinophil cationic protein and myeloperoxidase in nasal secretion as markers of inflammation in allergic rhinitis. Allergy. 1987 Nov;42(8):583–590. doi: 10.1111/j.1398-9995.1987.tb00388.x. [DOI] [PubMed] [Google Scholar]
  14. McCay P. B., Pfeifer P. M., Stipe W. H. Vitamin E protection of membrane lipids during electron transport functions. Ann N Y Acad Sci. 1972 Dec 18;203:62–73. doi: 10.1111/j.1749-6632.1972.tb27858.x. [DOI] [PubMed] [Google Scholar]
  15. Murlas C. G., Roum J. H. Sequence of pathologic changes in the airway mucosa of guinea pigs during ozone-induced bronchial hyperreactivity. Am Rev Respir Dis. 1985 Mar;131(3):314–320. doi: 10.1164/arrd.1985.131.3.314. [DOI] [PubMed] [Google Scholar]
  16. Naclerio R. M., Meier H. L., Kagey-Sobotka A., Adkinson N. F., Jr, Meyers D. A., Norman P. S., Lichtenstein L. M. Mediator release after nasal airway challenge with allergen. Am Rev Respir Dis. 1983 Oct;128(4):597–602. doi: 10.1164/arrd.1983.128.4.597. [DOI] [PubMed] [Google Scholar]
  17. O'Flaherty J. T., Wykle R. L. Biology and biochemistry of platelet-activating factor. Clin Rev Allergy. 1983 Sep;1(3):353–367. doi: 10.1007/BF02991226. [DOI] [PubMed] [Google Scholar]
  18. Patterson R., Bernstein P. R., Harris K. E., Krell R. D. Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. J Lab Clin Med. 1984 Sep;104(3):340–345. [PubMed] [Google Scholar]
  19. Proud D., Reynolds C. J., Lacapra S., Kagey-Sobotka A., Lichtenstein L. M., Naclerio R. M. Nasal provocation with bradykinin induces symptoms of rhinitis and a sore throat. Am Rev Respir Dis. 1988 Mar;137(3):613–616. doi: 10.1164/ajrccm/137.3.613. [DOI] [PubMed] [Google Scholar]
  20. Robertson D. N., Coyle A. J., Rhoden K. J., Grandordy B., Page C. P., Barnes P. J. The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. Am Rev Respir Dis. 1988 Jun;137(6):1317–1322. doi: 10.1164/ajrccm/137.6.1317. [DOI] [PubMed] [Google Scholar]
  21. Rubanyi G. M., Vanhoutte P. M. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol. 1986 May;250(5 Pt 2):H822–H827. doi: 10.1152/ajpheart.1986.250.5.H822. [DOI] [PubMed] [Google Scholar]
  22. Sanjar S., Aoki S., Boubekeur K., Chapman I. D., Smith D., Kings M. A., Morley J. Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs. Br J Pharmacol. 1990 Feb;99(2):267–272. doi: 10.1111/j.1476-5381.1990.tb14692.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Seltzer J., Bigby B. G., Stulbarg M., Holtzman M. J., Nadel J. A., Ueki I. F., Leikauf G. D., Goetzl E. J., Boushey H. A. O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol (1985) 1986 Apr;60(4):1321–1326. doi: 10.1152/jappl.1986.60.4.1321. [DOI] [PubMed] [Google Scholar]
  24. Spina D., McKenniff M. G., Coyle A. J., Seeds E. A., Tramontana M., Perretti F., Manzini S., Page C. P. Effect of capsaicin on PAF-induced bronchial hyperresponsiveness and pulmonary cell accumulation in the rabbit. Br J Pharmacol. 1991 May;103(1):1268–1274. doi: 10.1111/j.1476-5381.1991.tb12335.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Szarek J. L., Schmidt N. L. Hydrogen peroxide-induced potentiation of contractile responses in isolated rat airways. Am J Physiol. 1990 Apr;258(4 Pt 1):L232–L237. doi: 10.1152/ajplung.1990.258.4.L232. [DOI] [PubMed] [Google Scholar]
  26. Taylor S. L., Lamden M. P., Tappel A. L. Sensitive fluorometric method for tissue tocopherol analysis. Lipids. 1976 Jul;11(7):530–538. doi: 10.1007/BF02532898. [DOI] [PubMed] [Google Scholar]
  27. Venge P., Roxin L. E., Olsson I. Radioimmunoassay of human eosinophil cationic protein. Br J Haematol. 1977 Nov;37(3):331–335. doi: 10.1111/j.1365-2141.1977.tb01003.x. [DOI] [PubMed] [Google Scholar]
  28. Webber S. E., Morikawa T., Widdicombe J. G. PAF-induced muscarinic cholinoceptor hyperresponsiveness of ferret tracheal smooth muscle and gland secretion in vitro. Br J Pharmacol. 1992 Jan;105(1):230–237. doi: 10.1111/j.1476-5381.1992.tb14239.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES