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. 1983 Jul;155(1):420–423. doi: 10.1128/jb.155.1.420-423.1983

Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling.

S H Manes, G J Pruss, K Drlica
PMCID: PMC217697  PMID: 6345510

Abstract

Oxolinic acid reduced RNA synthesis rates whether chromosome supercoiling decreased, increased, or remained unchanged. Thus, inhibition of RNA synthesis by oxolinic acid appears to involve factors other than average DNA supercoiling level. Coumermycin A1 caused RNA synthesis rates to increase or decrease roughly in parallel with DNA supercoiling.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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