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. 1983 Nov;156(2):481–486. doi: 10.1128/jb.156.2.481-486.1983

Two proline porters in Escherichia coli K-12.

M E Stalmach, S Grothe, J M Wood
PMCID: PMC217857  PMID: 6355059

Abstract

Escherichia coli mutants defective at putP and putA lack proline transport via proline porter I and proline dehydrogenase activity, respectively. They retain a proline uptake system (proline porter II) that is induced during tryptophan-limited growth and are sensitive to the toxic L-proline analog, 3,4-dehydroproline. 3,4-Dehydroproline-resistant mutants derived from a putP putA mutant lack proline porter II. Auxotrophic derivatives derived from putP+ or putP bacteria can grow if provided with proline at low concentration (25 microM); those derived from the 3,4-dehydroproline-resistant mutants require high proline for growth (2.5 mM). We conclude that E. coli, like Salmonella typhimurium, possesses a second proline porter that is inactivated by mutations at the proP locus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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