Abstract
No definite conclusions relative to the etiology of toxemia of pregnancy in the rabbit can be drawn from the evidence obtained to date, but certain findings are suggestive and will be investigated further in future studies. These findings suggest that the disorder in the rabbit is a generic variation of eclampsia in man. The incidence, clinical manifestations and pathological lesions indicate that the disorder is of hypophyseal origin and that the association with pregnancy is due to altered activity of that gland in the terminal stages of gestation. Hereditary factors related to race and certain constitutional variations were associated with increased susceptibility, but their expression was apparently dependent upon environmental conditions. The association of widespread reproductive disturbances with the outbreak of toxemia suggests a causal relation, and it is assumed that the endocrine imbalance was a primary factor in their genesis and was induced by changed environmental conditions. The general response of the population was manifest in functional disturbances which were of minor severity in normal groups and were expressed as toxemia in inherently susceptible animals.
Full Text
The Full Text of this article is available as a PDF (1.0 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Greene H. S., Hu C. K., Brown W. H. A LETHAL DWARF MUTATION IN THE RABBIT WITH STIGMATA OF ENDOCRINE ABNORMALITY. Science. 1934 May 25;79(2056):487–488. doi: 10.1126/science.79.2056.487. [DOI] [PubMed] [Google Scholar]
- Greene H. S. RABBIT POX : III. REPORT OF AN EPIDEMIC WITH ESPECIAL REFERENCE TO EPIDEMIOLOGICAL FACTORS. J Exp Med. 1935 May 31;61(6):807–831. doi: 10.1084/jem.61.6.807. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greene H. S. RABBIT POX : IV. SUSCEPTIBILITY AS A FUNCTION OF CONSTITUTIONAL FACTORS. J Exp Med. 1935 Aug 31;62(3):305–329. doi: 10.1084/jem.62.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greene H. S. TOXEMIA OF PREGNANCY IN THE RABBIT : I. CLINICAL MANIFESTATIONS AND PATHOLOGY. J Exp Med. 1937 May 31;65(6):809–832. doi: 10.1084/jem.65.6.809. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hu C. K., Green H. S. A LETHAL MUTATION IN THE RABBIT WITH STIGMATA OF AN ACROMEGALIC DISORDER. Science. 1935 Jan 4;81(2088):25–26. doi: 10.1126/science.81.2088.25. [DOI] [PubMed] [Google Scholar]
- Rosahn P. D., Greene H. S. THE INFLUENCE OF INTRAUTERINE FACTORS ON THE FETAL WEIGHT OF RABBITS. J Exp Med. 1936 May 31;63(6):901–921. doi: 10.1084/jem.63.6.901. [DOI] [PMC free article] [PubMed] [Google Scholar]