Skip to main content
NCBI home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1951 Oct 31;94(5):415–430. doi: 10.1084/jem.94.5.415

THE EFFECT OF ADRENOCORTICOTROPIC HORMONE ON INFLAMMATION DUE TO TUBERCULIN HYPERSENSITIVITY AND TURPENTINE AND ON CIRCULATING ANTIBODY LEVELS

Charles K Osgood 1, Cutting B Favour 1
PMCID: PMC2180331  PMID: 14888823

Abstract

The treatment with adrenocorticotropic hormone of guinea pigs sensitized with heat-killed tubercle bacilli caused suppression of their skin reactivity to tuberculin. Similar animals treated with saline did not show this change. Normal guinea pigs treated with adrenocorticotropic hormone showed suppression of inflammation, but not necrosis, produced by intracutaneous oil of turpentine. There was slight, but probably not significant, diminution of inflammation during saline administration. Tuberculin complement-fixing antibody titers were not altered by either adrenocorticotropic hormone or saline administration. Adrenocorticotropic hormone produced marked eosinopenia and lymphopenia in guinea pigs.

Full Text

The Full Text of this article is available as a PDF (871.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BJØRNEBOE M., FISCHEL E. E., STOERK H. C. The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody. J Exp Med. 1951 Jan;93(1):37–48. doi: 10.1084/jem.93.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. D'ARCY HART P., REES R. J. W. Enhancing effect of cortisone on tuberculosis in the mouse. Lancet. 1950 Sep 23;2(6630):391–395. doi: 10.1016/s0140-6736(50)91344-4. [DOI] [PubMed] [Google Scholar]
  3. DE VRIES J. A. The effect of adrenocorticotrophic hormone on circulating antibody levels. J Immunol. 1950 Jul;65(1):1–5. [PubMed] [Google Scholar]
  4. DERBES V. J., DENT J. H., WEAVER N. K., VAUGHAN D. D. Response of tuberculin skin test to ACTH and cortisone in tuberculous guinea pigs. Proc Soc Exp Biol Med. 1950 Nov;75(2):423–426. doi: 10.3181/00379727-75-18218. [DOI] [PubMed] [Google Scholar]
  5. DOUGHERTY T. F., SCHNEEBELI G. L. Role of cortisone in regulation of inflammation. Proc Soc Exp Biol Med. 1950 Dec;75(3):854–859. doi: 10.3181/00379727-75-18368. [DOI] [PubMed] [Google Scholar]
  6. FISCHEL E. E., LeMAY M., KABAT E. A. The effect of adrenocorticotrophic hormone and X-ray on the amount of circulating antibody. J Immunol. 1949 Jan;61(1):89–93. [PubMed] [Google Scholar]
  7. Freund J., Opie E. L. SENSITIZATION AND ANTIBODY FORMATION WITH INCREASED RESISTANCE TO TUBERCULOUS INFECTION INDUCED BY HEAT KILLED TUBERCLE BACILLI. J Exp Med. 1938 Jul 31;68(2):273–298. doi: 10.1084/jem.68.2.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GERMUTH F. G., Jr, OTTINGER B. Effect of 17-hydroxy-11-dehydrocorticosterone (compound E) and of ACTH on arthus reaction and antibody formation in the rabbit. Proc Soc Exp Biol Med. 1950 Aug;74(4):815–823. doi: 10.3181/00379727-74-18058. [DOI] [PubMed] [Google Scholar]
  9. GLASER R. J., BERRY J. W., LOEB L. H., WOOD W. B., Jr, DAUGHADAY W. H. Effect of ACTH and cortisone in experimental streptococcal and pneumococcal infections. J Lab Clin Med. 1950 Nov;36(5):826–826. [PubMed] [Google Scholar]
  10. GROSS F. Unspezifische Beeinflussung entzundlicher Reaktionen. Schweiz Med Wochenschr. 1950 Jul 8;80(27):697–701. [PubMed] [Google Scholar]
  11. HACKEL D. B., PORTFOLIO A. G., KINNEY T. D. Experimental nephrotoxic nephritis in the rat treated with ACTH or cortisone. Proc Soc Exp Biol Med. 1950 Jun;74(2):458–460. doi: 10.3181/00379727-74-17939. [DOI] [PubMed] [Google Scholar]
  12. HAHN E. O., HOUSER H. B., RAMMELKAMP C. H., Jr, DENNY F. W., WANNAMAKER L. W. Effect of cortisone on acute streptococcal infections and poststreptococcal complications. J Clin Invest. 1951 Mar;30(3):274–281. doi: 10.1172/JCI102441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jaffe H. L. On Diminished Resistance Following Suprarenalectomy in the Rat and the Protection Afforded by Autoplastic Transplants. Am J Pathol. 1926 Sep;2(5):421–430. [PMC free article] [PubMed] [Google Scholar]
  14. KASS E. H., INGBAR S. H., FINLAND M. Effects of adrenocorticotropic hormone in pneumonia: clinical, bacteriological and serological studies. Ann Intern Med. 1950 Nov;33(5):1081–1098. doi: 10.7326/0003-4819-33-5-1081. [DOI] [PubMed] [Google Scholar]
  15. KNOWLTON A. I., LOEB E. N. The development of hypertension and nephritis in normal and adrenalectomized rats treated with cortisone. Proc Soc Exp Biol Med. 1949 Dec;72(3):722–725. doi: 10.3181/00379727-72-17556. [DOI] [PubMed] [Google Scholar]
  16. LEGER J., LEITH W., ROSE B. Effect of adrenocorticotrophic hormone on anaphylaxis in the guinea pig. Proc Soc Exp Biol Med. 1948 Dec;69(3):465–467. doi: 10.3181/00379727-69-16757. [DOI] [PubMed] [Google Scholar]
  17. LONG J. B., FAVOUR C. B. The ability of ACTH and cortisone to alter delayed type bacterial hypersensitivity. Bull Johns Hopkins Hosp. 1950 Sep;87(3):186–202. [PubMed] [Google Scholar]
  18. LURIE M. B., ZAPPASODI P., DANNENBERG A. M., Jr Constitutional factors in resistance to infection; the effect of cortisone on the pathogenesis of tuberculosis. Science. 1951 Mar 2;113(2931):234–237. doi: 10.1126/science.113.2931.234. [DOI] [PubMed] [Google Scholar]
  19. MIRICK G. S. The effect of adrenocorticotropic hormone and cortisone on antibody production in human beings. J Clin Invest. 1950 Jun;29(6):836–836. [PubMed] [Google Scholar]
  20. Marmorston-Gottesman J., Gottesman J. THE USE OF HISTAMINE AS A STANDARD TEST FOR DIMINISHED RESISTANCE IN SUPRARENALECTOMIZED RATS. J Exp Med. 1928 Mar 31;47(4):503–514. doi: 10.1084/jem.47.4.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Marmorston-Gottesman J., Perla D. IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : V. THE EFFECT OF REPEATED INJECTIONS OF SOLUTIONS CONTAINING SODIUM SALTS AND GLUCOSE ON THE HEMOLYSIN FORMATION OF NORMAL AND SUPRARENALECTOMIZED RATS. J Exp Med. 1929 Jun 30;50(1):93–102. doi: 10.1084/jem.50.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Marmorston-Gottesman J., Perla D., Vorzimer J. IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : VI a. TRYPANOSOMA LEWISI INFECTION IN NORMAL ALBINO RATS VI b. TRYPANOSOMA LEWISI INFECTION IN SUPRARENALECTOMIZED ADULT ALBINO RATS. J Exp Med. 1930 Sep 30;52(4):587–600. doi: 10.1084/jem.52.4.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Perla D., Marmorston-Gottesman J. IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : II. HEMOLYSIN FORMATION IN SUPRARENALECTOMIZED RATS. J Exp Med. 1928 Apr 30;47(5):723–740. doi: 10.1084/jem.47.5.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. STOLLERMAN G. H., RUBIN S. J., POLTZ C. M. Effect of cortisone on passively induced skin hypersensitivity in man. Proc Soc Exp Biol Med. 1951 Feb;76(2):261–265. doi: 10.3181/00379727-76-18456. [DOI] [PubMed] [Google Scholar]
  25. Scott W. J. THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE : I. THE SUSCEPTIBILITY OF ADRENALECTOMIZED RATS TO MORPHINE. J Exp Med. 1923 Oct 31;38(5):543–560. doi: 10.1084/jem.38.5.543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Scott W. J. THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE : II. THE TOXIC EFFECT OF KILLED BACTERIA IN ADRENALECTOMIZED RATS. J Exp Med. 1924 Feb 29;39(3):457–471. doi: 10.1084/jem.39.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Scott W. J. THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE : III. SUSCEPTIBILITY TO HISTAMINE AS A TEST OF ADRENAL DEFICIENCY. J Exp Med. 1928 Jan 31;47(2):185–191. doi: 10.1084/jem.47.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. WOODS A. C. Clinical and experimental observation on the use of ACTH and cortisone in ocular inflammatory disease. Am J Ophthalmol. 1950 Sep;33(9):1325–1349. doi: 10.1016/0002-9394(50)91827-7. [DOI] [PubMed] [Google Scholar]
  29. WOODWARD T. E., HALL H. E., DIAS-RIVERA R., HIGHTOWER J. A., MARTINEZ E., PARKER R. T. Treatment of typhoid fever. II. Control of clinical manifestations with cortisone. Ann Intern Med. 1951 Jan;34(1):10–19. doi: 10.7326/0003-4819-34-1-10. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES