Abstract
The specific polysaccharide of Type III pneumococcus, with only 0.05 per cent of N and 0.01 per cent of P, still shows almost maximal precipitation of a Type III antipneumococcus rabbit serum and the expected antigenicity in man. There is therefore no evidence that a prosthetic group is involved in these characteristic activities.
Full Text
The Full Text of this article is available as a PDF (205.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adams M. H., Roe A. S. A Partially Defined Medium for Cultivation of Pneumococcus. J Bacteriol. 1945 Apr;49(4):401–409. doi: 10.1128/jb.49.4.401-409.1945. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HEIDELBERGER M., DILAPI M. M., SIEGEL M., WALTER A. W. Persistence of antibodies in human subjects injected with pneumococcal polysaccharides. J Immunol. 1950 Nov;65(5):535–541. [PubMed] [Google Scholar]
- HEIDELBERGER M., MacLEOD C. M., DI LAPI M. M. The human antibody response to simultaneous injection of six specific polysaccharides of pneumococcus. J Exp Med. 1948 Sep 1;88(3):369–372. doi: 10.1084/jem.88.3.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Goebel W. F., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : THIRD PAPER. J Exp Med. 1925 Oct 31;42(5):727–745. doi: 10.1084/jem.42.5.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Kendall F. E. A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : IV. THE REACTION OF PNEUMOCOCCUS SPECIFIC POLYSACCHARIDES WITH HOMOLOGOUS RABBIT ANTISERA. J Exp Med. 1937 Apr 30;65(5):647–660. doi: 10.1084/jem.65.5.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Kendall F. E. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : THE DETERMINATION OF SMALL AMOUNTS OF A SPECIFIC POLYSACCHARIDE. J Exp Med. 1932 Mar 31;55(4):555–561. doi: 10.1084/jem.55.4.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Kendall F. E., Scherp H. W. THE SPECIFIC POLYSACCHARIDES OF TYPES I, II, AND III PNEUMOCOCCUS : A REVISION OF METHODS AND DATA. J Exp Med. 1936 Sep 30;64(4):559–572. doi: 10.1084/jem.64.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Macleod C. M., Kaiser S. J., Robinson B. ANTIBODY FORMATION IN VOLUNTEERS FOLLOWING INJECTION OF PNEUMOCOCCI OR THEIR TYPE-SPECIFIC POLYSACCHARIDES. J Exp Med. 1946 Mar 31;83(4):303–320. [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Macleod C. M., Markowitz H., Roe A. S. IMPROVED METHODS FOR THE PREPARATION OF THE SPECIFIC POLYSACCHARIDES OF PNEUMOCOCCUS. J Exp Med. 1950 Mar 31;91(4):341–349. doi: 10.1084/jem.91.4.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Macpherson C. F. QUANTITATIVE MICRO-ESTIMATION OF ANTIBODIES IN THE SERA OF MAN AND OTHER ANIMALS. Science. 1943 Apr 30;97(2522):405–406. doi: 10.1126/science.97.2522.405. [DOI] [PubMed] [Google Scholar]
- RECORD B. R., STACEY M. Some physical properties of the specific polysaccharides from the types I, II, and III pneumococcus. J Chem Soc. 1948 Oct;3:1561–1567. doi: 10.1039/jr9480001561. [DOI] [PubMed] [Google Scholar]