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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1954 Jan 31;99(2):125–132. doi: 10.1084/jem.99.2.125

SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER

THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C14TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER

Leon L Miller 1, William F Bale 1
PMCID: PMC2180344  PMID: 13130789

Abstract

Lysine-ε-C14-labeled plasma proteins produced by the normal rat and the isolated perfused rat liver have been fractionated by preparative zone electrophoresis. The isolated perfused liver incorporates lysine-ε-C14 into the plasma albumin, alpha globulin, and beta globulin (including fibrinogen) fractions. No significant C14 incorporation into the trichloracetic acid-precipitable proteins of the gamma globulin fraction was observed. Presumptive evidence indicates that the alpha globulins turn over more rapidly than any other major plasma protein fraction. The increased production of gamma globulins in liver disease is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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