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. 1961 Oct 31;114(5):791–806. doi: 10.1084/jem.114.5.791

THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS

John L Abruzzo 1, Charles L Christians 1
PMCID: PMC2180373  PMID: 13859099

Abstract

Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedimented rapidly with ultracentrifugation. The serologic properties of the RFLS were destroyed by mercaptoethanol. It reacted primarily with rabbit gamma globulin in an aggregated state (immune complexes or physically aggregated gamma globulin) and demonstrated cross-reactivity with human gamma globulin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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