Abstract
The effect of cortisone on the sequestration of (a) antibody-coated red cells and (b) incubated red cells was studied in rats. Cortisone administration inhibited the hepatic sequestration of red cells altered by non-immune as well as by immune injury. There was a latent period of 2 days between the institution of cortisone therapy and its first manifest effect on hepatic sequestration. The splenic sequestration of altered red cells was not inhibited by cortisone, and there was no inhibition of the sequestration of hemoglobin by either liver or spleen. It is suggested that steroids may inhibit hepatic sequestration through hemodynamic effects.
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- BAIKIE A. G., PIRRIE R. The effects of ACTH and cortisone in experimental haemolytic anaemias in guinea-pigs; studies on anaemias due to heterologous anti-red-cell-serum and on the anaemia of chronic lead poisoning. Scott Med J. 1958 Jun;3(6):264–273. doi: 10.1177/003693305800300606. [DOI] [PubMed] [Google Scholar]
- BENACERRAF B., HALPERN B. N., BIOZZI G., BENOS S. A. Quantitative study of the granulopectic activity of the reticulo-endothelial system. III. The effect of cortisone and nitrogen mustard on the regenerative capacity of the R.E.S. after saturation with carbon. Br J Exp Pathol. 1954 Apr;35(2):97–106. [PMC free article] [PubMed] [Google Scholar]
- BENACERRAF B., SEBESTYEN M. M., SCHLOSSMAN S. A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system. J Exp Med. 1959 Jul 1;110(1):27–48. doi: 10.1084/jem.110.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BJØRNEBOE M., FISCHEL E. E., STOERK H. C. The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody. J Exp Med. 1951 Jan;93(1):37–48. doi: 10.1084/jem.93.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHERTKOW G., DACIE J. V. Results of splenectomy in auto-immune haemolytic anaemia. Br J Haematol. 1956 Jul;2(3):237–249. [PubMed] [Google Scholar]
- CLEARKIN K. P. Effect of adrenocorticotropic hormone on clinical and experimental haemolytic anaemia. Lancet. 1952 Jan 26;1(6700):183–185. doi: 10.1016/s0140-6736(52)91409-8. [DOI] [PubMed] [Google Scholar]
- COLEMAN D. H., FINCH C. A. Effect of adrenal steroids in hereditary spherocytic anemia. J Lab Clin Med. 1956 Apr;47(4):602–610. [PubMed] [Google Scholar]
- CREGER W. P., TULLEY E. H., HANSEN D. G. A note on the effect of hydrocortisone on the microelectrophoretic characteristics of human red cell-antibody unions. J Lab Clin Med. 1956 May;47(5):686–690. [PubMed] [Google Scholar]
- CREPEA S. B., MAGNIN G. E., SEASTONE C. V. Effect of ACTH and cortisone on phagocytosis. Proc Soc Exp Biol Med. 1951 Aug;77(4):704–706. doi: 10.3181/00379727-77-18899. [DOI] [PubMed] [Google Scholar]
- DACIE J. V., CUTBUSH M. Specificity of auto-antibodies in acquired haemolytic anaemia. J Clin Pathol. 1954 Feb;7(1):18–21. doi: 10.1136/jcp.7.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAMESHEK W., KOMNINOS Z. D. The present status of treatment of autoimmune hemolytic anemia with ACTH and cortisone. Blood. 1956 Jul;11(7):648–664. [PubMed] [Google Scholar]
- DAMESHEK W., ROSENTHAL M. C., SCHWARTZ L. I. The treatment of acquired hemolytic anemia with adrenocorticotrophic hormone (ACTH). N Engl J Med. 1950 Jan 25;244(4):117–127. doi: 10.1056/NEJM195101252440401. [DOI] [PubMed] [Google Scholar]
- DAVIDSOHN I. Immunohematological studies in hemolytic anemia. J Am Med Assoc. 1954 Mar 6;154(10):818–821. doi: 10.1001/jama.1954.02940440016004. [DOI] [PubMed] [Google Scholar]
- DAVIDSON L. S. P., DUTHIE J. J. R., GIRDWOOD R. H., SINCLAIR R. J. G. Clinical trials of ACTH in haemolytic anaemia. Br Med J. 1951 Mar 31;1(4708):657–660. doi: 10.1136/bmj.1.4708.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAVIS L. J., KENNEDY A. C., BAIKIE A. G., BROWN A. Haemolytic anaemias of various types treated with ACTH and cortisone; report of ten cases, including one of acquired type in which erythropoietic arrest occurred during a crisis. Glasgow Med J. 1952 Jul;33(7):263–285. [PMC free article] [PubMed] [Google Scholar]
- EDELMANN A., GORDON A. S., REICHARD S. M. Endocrine influences upon the uptake of colloidal thorium by the reticuloendothelial system. J Lab Clin Med. 1956 Sep;48(3):431–441. [PubMed] [Google Scholar]
- EISENTRAUT A. M., SUTHERLAND D. A. The direct Coombs test in lead poisoning. Blood. 1956 Nov;11(11):1024–1031. [PubMed] [Google Scholar]
- FELDMAN J. D., RACHMILEWITZ M. The adrenal cortex and hemolysis. II. Immune serum. Acta Haematol. 1954 Feb;11(2):129–133. doi: 10.1159/000204541. [DOI] [PubMed] [Google Scholar]
- FREEDMAN A. L., BARR P. S., BRODY E. A. Hemolytic anemia due to quinidine: observations on its mechanism. Am J Med. 1956 May;20(5):806–816. doi: 10.1016/0002-9343(56)90164-4. [DOI] [PubMed] [Google Scholar]
- FUDENBERG H., BARRY I., DAMESHEK W. The erythrocyte-coating substance in autoimmune hemolytic disease: its nature and significance. Blood. 1958 Mar;13(3):201–215. [PubMed] [Google Scholar]
- GARDNER F. H., McELFRESH A. E., HARRIS J. W., DIAMOND L. K. The effect of adrenocorticotrophic hormone (ACTH) in idiopathic acquired hemolytic anemia as related to the hemolytic mechanisms. J Lab Clin Med. 1951 Mar;37(3):444–457. [PubMed] [Google Scholar]
- GERMUTH F. G., Jr, OTTINGER B., OYAMA J. The influence of cortisone on the evolution of acute infection and the development of immunity. Bull Johns Hopkins Hosp. 1952 Jul;91(1):22–47. [PubMed] [Google Scholar]
- GREEN H., BARROW P., GOLDBERG B. Effect of antibody and complement on permeability control in ascites tumor cells and erythrocytes. J Exp Med. 1959 Nov 1;110:699–713. doi: 10.1084/jem.110.5.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAHN E. O., HOUSER H. B., RAMMELKAMP C. H., Jr, DENNY F. W., WANNAMAKER L. W. Effect of cortisone on acute streptococcal infections and poststreptococcal complications. J Clin Invest. 1951 Mar;30(3):274–281. doi: 10.1172/JCI102441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARRIS J. W. Studies on the mechanism of a drug-induced hemolytic anemia. J Lab Clin Med. 1956 May;47(5):760–775. [PubMed] [Google Scholar]
- HAVENS W. P., Jr, SHAFFER J. M., HOPKE C. J., Jr The effect of ACTH and cortisone on the concentration of circulating diphtheria antitoxin. J Immunol. 1952 Apr;68(4):389–400. [PubMed] [Google Scholar]
- HEWITT W. C., Jr, WHEBY M., CROSBY W. H. Effect of prednisolone on incompatible blood transfusions. Transfusion. 1961 May-Jun;1:184–186. doi: 10.1111/j.1537-2995.1961.tb00038.x. [DOI] [PubMed] [Google Scholar]
- HIRSCH J. G., CHURCH A. B. Adrenal steroids and infection: the effect of cortisone administration on polymorphonuclear leukocytic functions and on serum opsonins and bactericidins. J Clin Invest. 1961 May;40:794–798. doi: 10.1172/JCI104312. [DOI] [PMC free article] [PubMed] [Google Scholar]
- INGLE D. J., MEEKS R. C., BEARY D. F. Time-response effect of cortisone upon liver glycogen in the rat. Proc Soc Exp Biol Med. 1953 Oct;84(1):239–240. doi: 10.3181/00379727-84-20602. [DOI] [PubMed] [Google Scholar]
- JANDL J. H., CASTLE W. B. Agglutination of sensitized red cells by large anisometric molecules. J Lab Clin Med. 1956 May;47(5):669–685. [PubMed] [Google Scholar]
- JANDL J. H., GREENBERG M. S., YONEMOTO R. H., CASTLE W. B. Clinical determination of the sites of red cell sequestration in hemolytic anemias. J Clin Invest. 1956 Aug;35(8):842–867. doi: 10.1172/JCI103338. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JANDL J. H., JONES A. R., CASTLE W. B. The destruction of red cells by antibodies in man. I. Observations of the sequestration and lysis of red cells altered by immune mechanisms. J Clin Invest. 1957 Oct;36(10):1428–1459. doi: 10.1172/JCI103542. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JANDL J. H., KAPLAN M. E. The destruction of red cells by antibodies in man. III. Quantitative factors influencing the patterns of hemolysis in vivo. J Clin Invest. 1960 Jul;39:1145–1156. doi: 10.1172/JCI104129. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JANDL J. H., SIMMONS R. L. The agglutination and sensitization of red cells by metallic cations: interactions between multivalent metals and the red-cell membrane. Br J Haematol. 1957 Jan;3(1):19–38. doi: 10.1111/j.1365-2141.1957.tb05768.x. [DOI] [PubMed] [Google Scholar]
- JANDL J. H., TOMLINSON A. S. The destruction of red cells by antibodies in man. II. Pyrogenic, leukocytic and dermal responses to immune hemolysis. J Clin Invest. 1958 Aug;37(8):1202–1228. doi: 10.1172/JCI103710. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KASS E. H., FINLAND M. Adrenocortical hormones in infection and immunity. Annu Rev Microbiol. 1953;7:361–388. doi: 10.1146/annurev.mi.07.100153.002045. [DOI] [PubMed] [Google Scholar]
- KERBY G. P., BARRETT J. A., Jr The effect of hydrocortisone and of piromen in vitro on leukocytes of patients receiving ACTH and cortisone therapy. J Clin Invest. 1954 May;33(5):725–731. doi: 10.1172/JCI102941. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LARSON D. L., TOMLINSON L. J. Quantitative antibody studies in man. I. The effect of adrenal insufficiency and of cortisone on the level of circulating antibodies. J Clin Invest. 1951 Dec;30(122):1451–1455. doi: 10.1172/JCI102552. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEAHY R. H., MORGAN H. R. The inhibition by cortisone of the cytotoxic activity of PPD on tuberculin-hypersensitive cells in tissue culture. J Exp Med. 1952 Dec;96(6):549–554. doi: 10.1084/jem.96.6.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEWIS S. M., SZUR L., DACIE J. V. The pattern of erythrocyte destruction in haemolytic anaemia, as studied with radioactive chromium. Br J Haematol. 1960 Apr;6:122–139. doi: 10.1111/j.1365-2141.1960.tb06224.x. [DOI] [PubMed] [Google Scholar]
- LONG D. A., SHEWELL J. A species difference with regard to the effect of cortisone acetate on body weight, gamma-globulin and circulating antitoxin levels. J Hyg (Lond) 1956 Dec;54(4):452–460. doi: 10.1017/s0022172400044739. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MAGEE P. N., PALMER A. A. The absorption of particles from the peritoneal cavity in rats and mice treated with cortisone. Br J Exp Pathol. 1953 Aug;34(4):458–463. [PMC free article] [PubMed] [Google Scholar]
- MARTIN S. P., KERBY G. P. Effect of adrenal hormone overdosage on bacterial removal by the splanchnic viscera. Proc Soc Exp Biol Med. 1952 Oct;81(1):73–75. doi: 10.3181/00379727-81-19781. [DOI] [PubMed] [Google Scholar]
- MEYERS M. C., MILLER S., LINMAN J. W., BETHELL F. H. The use of ACTH and cortisone in idiopathic thrombocytopenic purpura and idiopathic acquired hemolytic anemia. Ann Intern Med. 1952 Aug;37(2):352–361. doi: 10.7326/0003-4819-37-2-352. [DOI] [PubMed] [Google Scholar]
- MIESCHER P. Le mécanisme de l'erythroclasie a l'état normal. Rev Hematol. 1956 Jun-Jul;11(3):248–259. [PubMed] [Google Scholar]
- MIRICK G. S. The effects of ACTH and cortisone on antibodies in human beings. Bull Johns Hopkins Hosp. 1951 Apr;88(4):332–351. [PubMed] [Google Scholar]
- MUIRHEAD E. E., GROVES M., BRYAN S. Positive direct Coombs test induced by phenylhydrazine. J Clin Invest. 1954 Dec;33(12):1700–1711. doi: 10.1172/JCI103050. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PACKER J. T., GREENDYKE R. M., SWISHER S. N. The inhibition of erythrophagocytosis in vitro by corticosteroids. Trans Assoc Am Physicians. 1960;73:93–102. [PubMed] [Google Scholar]
- REBUCK J. W., MELLINGER R. C. Interruption by topical cortisone of leukocytic cycles in acute inflammation in man. Ann N Y Acad Sci. 1953 Jul 17;56(4):715–732. doi: 10.1111/j.1749-6632.1953.tb27394.x. [DOI] [PubMed] [Google Scholar]
- TISCHENDORF W., ECKLEBE G., THOFERN E. ACTH und experimentelle hämolytische Anämien. Z Gesamte Exp Med. 1952 Jan;118(3):203–212. [PubMed] [Google Scholar]
- WEINER W., BATTEY D. A., CLEGHORN T. E., MARSON F. G. W., MEYNELL M. J. Serological findings in a case of haemolytic anaemia, with some general observations on the pathogenesis of this syndrome. Br Med J. 1953 Jul 18;2(4828):125–128. doi: 10.1136/bmj.2.4828.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WHITE R. G., MARSHALL A. H. E. Effect of cortisone on pneumococcal bacteraemia. Lancet. 1951 Apr 21;1(6660):891–892. doi: 10.1016/s0140-6736(51)91273-1. [DOI] [PubMed] [Google Scholar]
- WIENER A. S., UNGER L. J., COHEN L., FELDMAN J. Type-specific cold auto-antibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions: biologic test with bovine red cells. Ann Intern Med. 1956 Feb;44(2):221–240. doi: 10.7326/0003-4819-44-2-221. [DOI] [PubMed] [Google Scholar]
- WINTROBE M. M., CARTWRIGHT G. E., PALMER J. G., KUHNS W. J., SAMUELS L. T. Effect of corticotrophin and cortisone on the blood in various disorders in man. AMA Arch Intern Med. 1951 Sep;88(3):310–336. doi: 10.1001/archinte.1951.03810090041004. [DOI] [PubMed] [Google Scholar]