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. 1961 Nov 30;114(6):987–996. doi: 10.1084/jem.114.6.987

THE VACUOLATING VIRUS OF MONKEYS

II. VIRUS MORPHOLOGY AND INTRANUCLEAR DISTRIBUTION WITH SOME HISTOCHEMICAL OBSERVATIONS

W H Gaylord Jr 1, G-D Hsiung 1
PMCID: PMC2180416  PMID: 13897378

Abstract

Cells infected with the vacuolating virus, SV40, respond by swelling to several times their normal volume. Within enlarged nuclei, virus-containing inclusions appear which are acidophilic and Feulgen-positive. The formation of nuclear inclusions is followed by the appearance of cytoplasmic vacuoles and then shrinkage of the cell. Inclusions were found to exhibit unique double staining when a light-green counterstain was used in the Feulgen reaction. The virus is of low electron density, round, and 300 A in diameter. It occurs in large numbers, singly and in short chains, and it appears to multiply at the expense of chromatin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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