Skip to main content

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1963 Jan 1;117(1):139–147. doi: 10.1084/jem.117.1.139

THE MECHANISM OF BLOCKADE OF THE RETICULOENDOTHELIAL SYSTEM

I MacKay Murray 1
PMCID: PMC2180430  PMID: 13936766

Abstract

Rats were injected intravenously with various particulate materials with and without the addition of various stabilizing agents. One hour after the injection of the blockading colloid, a tracer dose of similar or different colloidal material was injected. A half-time clearance rate of the tracer dose greater than 4 minutes was taken as evidence of blockade of the RES. Blockade of the tracer dose occurred when the surface properties of the particles in both blockading and tracer doses were identical. Different particles stabilized by the same agent behaved as identical particles and identical particles stabilized by different agents behaved as different particles. The opsonization of a tracer dose of gelatin-stabilized colloid in vitro by a specific globulin fraction obtained from heterologous and homologous plasma prevented its blockade, while opsonization of both blockading and tracer doses with the same proteins resulted in blockade. However, when both blockading and tracer doses were opsonized with isologous globulins, blockade did not occur.

Full Text

The Full Text of this article is available as a PDF (518.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIOZZI G., BENACERRAF B., HALPERN B. N. Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity. Br J Exp Pathol. 1953 Aug;34(4):441–457. [PMC free article] [PubMed] [Google Scholar]
  2. BOEHME D., DUBOS R. J. The effect of bacterial constituents on the resistance of mice to heterologous infection and on the activity of their reticulo-endothelial system. J Exp Med. 1958 Apr 1;107(4):523–536. doi: 10.1084/jem.107.4.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beeson P. B., Technical Assistance of Elizabeth Roberts TOLERANCE TO BACTERIAL PYROGENS : II. ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM. J Exp Med. 1947 Jun 30;86(1):39–44. doi: 10.1084/jem.86.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. JENKIN C. R., ROWLEY D. The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system. J Exp Med. 1961 Sep 1;114:363–374. doi: 10.1084/jem.114.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. MCKENNA J. M., ZWEIFACH B. W. Reticulo-endothelial system in relation to drum shock. Am J Physiol. 1956 Nov;187(2):263–268. doi: 10.1152/ajplegacy.1956.187.2.263. [DOI] [PubMed] [Google Scholar]
  6. MURRAY I. M., KATZ M. Factors affecting the rate of removal of gelatin-stabilized radiogold colloid from the blood. I. The retardation of the radiogold disappearance rate by gelatin. J Lab Clin Med. 1955 Aug;46(2):263–269. [PubMed] [Google Scholar]
  7. Robertson O. H., Sia R. H. STUDIES ON PNEUMOCOCCUS GROWTH INHIBITION : VII. THE RELATION OF OPSONINS TO NATURAL RESISTANCE AGAINST PNEUMOCOCCUS INFECTION. J Exp Med. 1927 Jul 31;46(2):239–262. doi: 10.1084/jem.46.2.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. SCHMID K., ROSA E. C., MACNAIR M. B. Fractionation of the proteins of human synovial fluid and plasma. J Biol Chem. 1956 Apr;219(2):769–780. [PubMed] [Google Scholar]
  9. Ward H. K., Enders J. F. AN ANALYSIS OF THE OPSONIC AND TROPIC ACTION OF NORMAL AND IMMUNE SERA BASED ON EXPERIMENTS WITH THE PNEUMOCOCCUS. J Exp Med. 1933 Mar 31;57(4):527–547. doi: 10.1084/jem.57.4.527. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES