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. 1973 Jul 1;138(1):300–305. doi: 10.1084/jem.138.1.300

MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY

Joan L Press 1, Norman R Klinman 1
PMCID: PMC2180547  PMID: 4736831

Abstract

The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell.

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Selected References

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