Abstract
Surface radioiodination of lymphocytes by the lactoperoxidase procedure has permitted demonstration of an assortment of different antibodies to lymphocytes in the sera of patients with systemic lupus erythematosus. One type of antibody proved of special interest because it appeared to be associated with inhibition of the responder cells in the mixed leukocyte culture reactions. This reacted with an antigen on T cells and thymocytes which on sodium dodecyl sulfate acrylamide gel electrophoresis showed a molecular weight of approximately 15,000 daltons. The possible relation of this antigen to T cell receptors and products of immune response genes is discussed.
Full Text
The Full Text of this article is available as a PDF (310.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bach F. H., Widmer M. B., Bach M. L., Klein J. Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse. J Exp Med. 1972 Dec 1;136(6):1430–1444. doi: 10.1084/jem.136.6.1430. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baur S., Vitetta E. S., Sherr C. J., Schenkein I., Uhr J. W. Isolation of heavy and light chains of immunoglobulin from the surfaces of lymphoid cells. J Immunol. 1971 Apr;106(4):1133–1135. [PubMed] [Google Scholar]
- Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
- Brooks W. H., Netsky M. G., Normansell D. E., Horwitz D. A. Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor. J Exp Med. 1972 Dec 1;136(6):1631–1647. doi: 10.1084/jem.136.6.1631. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ceppellini R., Bonnard G. D., Coppo F., Miggiano V. C., Pospisil M., Curtoni E. S., Pellegrino M. Transplantation antigens: introductory symposium. Mixed leukocyte cultures and HL-A antigens. I. Reactivity of young fetuses, newborns and mothers at delivery. Transplant Proc. 1971 Mar;3(1):58–63. [PubMed] [Google Scholar]
- Hartzman R. J., Segall M., Bach M. L., Bach F. H. Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report. Transplantation. 1971 Mar;11(3):268–273. doi: 10.1097/00007890-197103000-00005. [DOI] [PubMed] [Google Scholar]
- Hauptfeld V., Klein D., Klein J. Serological identification of an Ir-region product. Science. 1973 Jul 13;181(4095):167–169. doi: 10.1126/science.181.4095.167. [DOI] [PubMed] [Google Scholar]
- Lies R. B., Messner R. P., Williams R. C., Jr Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum. 1973 May-Jun;16(3):369–375. doi: 10.1002/art.1780160312. [DOI] [PubMed] [Google Scholar]
- Revillard J. P., Robert M., Betuel H., Latour M., Bonneau M., Brochier J., Traeger J. Inhibition of the mixed lymphocyte reaction by antibodies. Transplant Proc. 1972 Jun;4(2):173–176. [PubMed] [Google Scholar]
- Yunis E. J., Amos D. B. Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031–3035. doi: 10.1073/pnas.68.12.3031. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van Rood J. J., Koch C. T., van Hooff J. P., van Leeuwen A., van den Tweel J. G., Frederiks E., Schippers H. M., Hendriks G., van der Steen G. J. Graft survival in unrelated donor--recipient pairs matched for MLC and HL-A. Transplant Proc. 1973 Mar;5(1):409–414. [PubMed] [Google Scholar]