Abstract
The lymphocytosis-promoting factor of Bordetella pertussis is a potent mitogen for murine lymphocytes in vitro. The stimulatory response was not the result of specific antigen stimulation. Spleen and lymph node cells were responsive, whereas normal thymocytes were unresponsive. However, DNA replication was induced in cortisone-resistant thymocytes by lymphocytosis-promoting factor (LPF). Bone marrow cells were not stimulated by LPF.
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- Adler A., Morse S. I. Interaction of lymphoid and nonlymphoid cells with the lymphocytosis-promoting factor of Bordetella pertussis. Infect Immun. 1973 Mar;7(3):461–467. doi: 10.1128/iai.7.3.461-467.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Athanassiades T. J., Morse S. I. Lymphocytosis induced in mice by supernatant fluids of Bordetella pertussis cultures: a histopathological study. Blood. 1973 Oct;42(4):611–621. [PubMed] [Google Scholar]
- Blomgren H., Svedmyr E. In vitro stimulation of mouse thymus cells by PHA and allogeneic cells. Cell Immunol. 1971 Aug;2(4):285–299. doi: 10.1016/0008-8749(71)90063-3. [DOI] [PubMed] [Google Scholar]
- Iwasa S., Yoshikawa T., Fukumura K., Kurokawa M. Effects of the lymphocytosis-promoting factor from Bordetella pertussis on the function and potentiality of lymphocytes. I. Effect on the ability of lymphocytes to recirculate in the body. Jpn J Med Sci Biol. 1970 Feb;23(1):47–60. doi: 10.7883/yoken1952.23.47. [DOI] [PubMed] [Google Scholar]
- Janossy G., Greaves M. F. Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens. Clin Exp Immunol. 1971 Oct;9(4):483–498. [PMC free article] [PubMed] [Google Scholar]
- Kong A. S., Morse S. I. The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells. J Exp Med. 1977 Jan 1;145(1):163–174. doi: 10.1084/jem.145.1.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moorhead J. F., Connolly J. J., McFarland W. Factors affecting the reactivity of human lymphocytes in vitro. I. Cell number, duration of culture and surface area. J Immunol. 1967 Aug;99(2):413–419. [PubMed] [Google Scholar]
- Morse S. I., Barron B. A. Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. 3. The distribution of transfused lymphocytes in pertussis-treated and normal mice. J Exp Med. 1970 Oct 1;132(4):663–672. doi: 10.1084/jem.132.4.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morse S. I., Morse J. H. Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis. J Exp Med. 1976 Jun 1;143(6):1483–1502. doi: 10.1084/jem.143.6.1483. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morse S. I., Riester S. K. Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. I. Radioautographic analysis of the circulating cells in mice undergoing pertussis-induced hyperleukocytosis. J Exp Med. 1967 Mar 1;125(3):401–408. doi: 10.1084/jem.125.3.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morse S. I., Riester S. K. Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. II. The effect of pertussis vaccine on the thoracic duct lymph and lymphocytes of mice. J Exp Med. 1967 Apr 1;125(4):619–628. doi: 10.1084/jem.125.4.619. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parker C. W., Morse S. I. The effect of Bordetella pertussis on lymphocyte cyclic AMP metabolism. J Exp Med. 1973 Apr 1;137(4):1078–1090. doi: 10.1084/jem.137.4.1078. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taub R. N., Rosett W., Adler A., Morse S. I. Distribution of labeled lymph node cells in mice during the lymphocytosis induced by Bordetella pertussis. J Exp Med. 1972 Dec 1;136(6):1581–1593. doi: 10.1084/jem.136.6.1581. [DOI] [PMC free article] [PubMed] [Google Scholar]