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. 1977 May 1;145(5):1405–1410. doi: 10.1084/jem.145.5.1405

Transfer of experimental allergic encephalomyelitis in Lewis rats using supernates of incubated sensitized lymph node cells

PMCID: PMC2180665  PMID: 300784

Abstract

Supernates derived from incubated lymph node cells of Lewis rats sensitized to guinea pig spinal cord-Freund's adjuvant transfer experimental allergic encephalomyelitis (EAE) to syngeneic recipients. EAE supernatant transfer activity (EAE-STA) is not demonstrable in supernates derived from LNC of control donors not sensitized to nervous tissue. After addition of brain antigen to active supernates, EAE-STA is not longer demonstrable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Flad H. D., Paterson P. Y., Mischer P. A. In vitro effects of phytohemagglutinin and brain antigen on cell transfer of experimental autoimmune encephalomyelitis in Lewis rats. J Immunol. 1968 Mar;100(3):647–653. [PubMed] [Google Scholar]
  2. Gonatas N. K., Howard J. C. Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells. Science. 1974 Nov 29;186(4166):839–841. doi: 10.1126/science.186.4166.839. [DOI] [PubMed] [Google Scholar]
  3. Guthrie R. K., Ellis W. L., Brock C. H. Contact hypersensitivity to simple chemicals. Incubation of sensitized guinea pig peritoneal exudate cells. Proc Soc Exp Biol Med. 1967 Oct;126(1):1–5. doi: 10.3181/00379727-126-32351. [DOI] [PubMed] [Google Scholar]
  4. Levine S., Sowinski R. Passive transfer of allergic adrenalitis and encephalomyelitis with whole blood. Proc Soc Exp Biol Med. 1968 Oct;129(1):221–222. doi: 10.3181/00379727-129-33290. [DOI] [PubMed] [Google Scholar]
  5. Ortiz-Ortiz L., Weigle W. O. Cellular events in the induction of experimental allergic encephalomyelitis in rats. J Exp Med. 1976 Sep 1;144(3):604–616. doi: 10.1084/jem.144.3.604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. PATERSON P. Y. Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J Exp Med. 1960 Jan 1;111:119–136. doi: 10.1084/jem.111.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Paterson P. Y. Adjuvants, cell-mediated immune responses and autoimmune disease. J Reticuloendothel Soc. 1973 Nov;14(5):426–440. [PubMed] [Google Scholar]
  8. Paterson P. Y., Drobish D. G., Hanson M. A., Jacobs A. F. Induction of experimental allergic encephalomyelitis in Lewis rats. Int Arch Allergy Appl Immunol. 1970;37(1):26–40. doi: 10.1159/000230217. [DOI] [PubMed] [Google Scholar]
  9. Paterson P. Y. Experimental allergic encephalomyelitis and autoimmune disease. Adv Immunol. 1966;5:131–208. doi: 10.1016/s0065-2776(08)60273-4. [DOI] [PubMed] [Google Scholar]
  10. Paterson P. Y., Richarson W. P., Drobish D. G. Cellular transfer of experimental allergic encephalomyelitis: altered disease pattern in irradiated recipient lewis rats. Cell Immunol. 1975 Mar;16(1):48–59. doi: 10.1016/0008-8749(75)90184-7. [DOI] [PubMed] [Google Scholar]
  11. Rauch H. C., Griffin J. Passive transfer studies in experimental allergic encephalomyelitis. Int Arch Allergy Appl Immunol. 1969;36(Suppl):387–400. [PubMed] [Google Scholar]
  12. Stone S. H., Lerner E. M., 2nd, Goode J. H. Adoptive autoimmune encephalomyelitis in inbred guinea pigs: immunological and histological aspects. Science. 1968 Mar 1;159(3818):995–997. doi: 10.1126/science.159.3818.995. [DOI] [PubMed] [Google Scholar]
  13. Whitehouse D. J., Whitehouse M. W., Pearson C. M. Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature. 1969 Dec 27;224(5226):1322–1322. doi: 10.1038/2241322a0. [DOI] [PubMed] [Google Scholar]

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