Abstract
Mice infected with Trichinella spiralis were depleted of eosinophils by repeated administration of rabbit anti-mouse eosinophil serum. There was no effect on the spontaneous expulsion of adult worms from the small intestines, but the numbers of larvae in the muscles were almost doubled. It is concluded that eosinophils contribute to resistance to the systemic phase of trichinosis.
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Selected References
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- Basten A., Beeson P. B. Mechanism of eosinophilia. II. Role of the lymphocyte. J Exp Med. 1970 Jun 1;131(6):1288–1305. doi: 10.1084/jem.131.6.1288. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Basten A., Boyer M. H., Beeson P. B. Mechanism of eosinophilia. I. Factors affecting the eosinophil response of rats to Trichinella spiralis. J Exp Med. 1970 Jun 1;131(6):1271–1287. doi: 10.1084/jem.131.6.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Butterworth A. E., Sturrock R. F., Houba V., Mahmoud A. A., Sher A., Rees P. H. Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature. 1975 Aug 28;256(5520):727–729. doi: 10.1038/256727a0. [DOI] [PubMed] [Google Scholar]
- CAMPBELL W. C. IMMUNIZING EFFECT OF ENTERAL AND ENTERAL-PARENTERAL INFECTIONS OF TRICHINELLA SPIRALIS IN MICE. J Parasitol. 1965 Apr;51:185–194. [PubMed] [Google Scholar]
- Grove D. I., Warren K. S. Effects on murine trichinosis of niridazole, a suppressant of cellular but not humoral immunological responses. Ann Trop Med Parasitol. 1976 Dec;70(4):449–453. doi: 10.1080/00034983.1976.11687146. [DOI] [PubMed] [Google Scholar]
- Larsh J. E., Jr Allergic inflammation as a hypothesis for the expulsion of worms from tissues: a review. Exp Parasitol. 1975 Apr;37(2):251–266. doi: 10.1016/0014-4894(75)90077-6. [DOI] [PubMed] [Google Scholar]
- Mahmoud A. A., Warren K. S., Boros D. I. Production of a rabbit antimouse eosinophil serum with no cross-reactivity to neutrophils. J Exp Med. 1973 Jun 1;137(6):1526–1531. doi: 10.1084/jem.137.6.1526. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mahmoud A. A., Warren K. S., Graham R. C., Jr Antieosinophil serum and the kinetics of eosinophilia in Schistosomiasis mansoni. J Exp Med. 1975 Sep 1;142(3):560–574. doi: 10.1084/jem.142.3.560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mahmoud A. A., Warren K. S., Peters P. A. A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum. J Exp Med. 1975 Oct 1;142(4):805–813. doi: 10.1084/jem.142.4.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Warren K. S., Karp R., Pelley R. P., Mahmoud A. A. The eosinophil stimulation promoter test in murine and human Trichinella spiralis infection. J Infect Dis. 1976 Sep;134(3):277–280. doi: 10.1093/infdis/134.3.277. [DOI] [PubMed] [Google Scholar]