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. 1977 Jul 1;146(1):277–281. doi: 10.1084/jem.146.1.277

Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi

PMCID: PMC2180731  PMID: 327014

Abstract

Human erythrocytes lacking various blood group determinants were susceptible to invasion by Plasmodium falciparum including Duffy- negative erythrocytes that are refractory to invasion by Plasmodium knowlesi. Erythrocytes treated with trypsin or neuraminidase had reduced susceptibility of P. falciparum and normal susceptibility to P. knowlesi. Chymotrypsin treatment (0.1 mg/ml) blocked invasion only by P. knowlesi. The differential effect of enzymatic cleavage of determinats from the erythrocyte surface on invasion by these parasites suggests that P. falciparum and P. knowlesi interact with different determinants on the erythrocyte surface.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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