Abstract
The allotype of the sixth component of complement was determined in a patient before and after liver transplantation. The C6 phenotype changed from A before transplantation to B (the donor phenotype) within 10 days of the transplant and remained wholly of the donor phenotype at 17 wk. This demonstrates that the liver is the exclusive or predominant site of C6 synthesis in vivo in man.
Full Text
The Full Text of this article is available as a PDF (125.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alper C. A., Johnson A. M., Birtch A. G., Moore F. D. Human C'3: evidence for the liver as the primary site of synthesis. Science. 1969 Jan 17;163(3864):286–288. doi: 10.1126/science.163.3864.286. [DOI] [PubMed] [Google Scholar]
- Rother U., Thorbecke G. J., Stecher-Levin V. J., Hurlimann J., Rother K. Formation of C'-6 by rabbit liver tissue in vitro. Immunology. 1968 May;14(5):649–655. [PMC free article] [PubMed] [Google Scholar]
- Ruddy S., Colten H. R. Rheumatoid arthritis. Biosynthesis of complement proteins by synovial tissues. N Engl J Med. 1974 Jun 6;290(23):1284–1288. doi: 10.1056/NEJM197406062902304. [DOI] [PubMed] [Google Scholar]