Abstract
A glycoprotein of mol wt ca. 18,000 daltons isolated from cured tobacco leaves (TGP-L) and from cigarette smoke condensate (TGP-CSC) activated factor XII in normal human plasma in vitro as measured by (a) shortening of the partial thromboplastin time, (b) shortening of the lysis time of euglobulin clots, and (c) generation of kinin activity. These effects were not demonstrable in plasma deficient in factor XII. The capacity of TGP-L and TGP-CSC to activate factor XII was shown to depend on the presence of rutin, a substance chemically similar to quercetin and ellagic acid, which are known activators of factor XII. Rutin and rutin coupled to bovine serum albumin, but not bovine serum albumin alone, were also demonstrated to activate factor XII. The presence in cigarette smoke of material that is both allergenic and capable of activating factor XII of the intrinsic pathway of coagulatin may be important to the pathogenesis of cardiovascular and pulmonary disease associated with cigarette smoking.
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- AUERBACH O., STOUT A. P., HAMMOND E. C., GARFINKEL L. SMOKING HABITS AND AGE IN RELATION TO PULMONARY CHANGES. RUPTURE OF ALVEOLAR SEPTUMS, FIBROSIS AND THICKENING OF WALLS OF SMALL ARTERIES AND ARTERIOLES. N Engl J Med. 1963 Nov 14;269:1045–1054. doi: 10.1056/NEJM196311142692001. [DOI] [PubMed] [Google Scholar]
- Auerbach O., Hammond E. C., Garfinkel L. Smoking in relation to atherosclerosis of the coronary arteries. N Engl J Med. 1965 Oct 7;273(15):775–779. doi: 10.1056/NEJM196510072731501. [DOI] [PubMed] [Google Scholar]
- Becker C. G., Dubin T., Wiedemann H. P. Hypersensitivity to tobacco antigen. Proc Natl Acad Sci U S A. 1976 May;73(5):1712–1716. doi: 10.1073/pnas.73.5.1712. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Becker E. L., Henson P. M. In vitro studies of immunologically induced secretion of mediators from cells and related phenomena. Adv Immunol. 1973;17:93–193. doi: 10.1016/s0065-2776(08)60732-4. [DOI] [PubMed] [Google Scholar]
- Bianco C., Eden A., Cohn Z. A. The induction of macrophage spreading: role of coagulation factors and the complement system. J Exp Med. 1976 Dec 1;144(6):1531–1544. doi: 10.1084/jem.144.6.1531. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Griffin J. H., Cochrane C. G. Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2554–2558. doi: 10.1073/pnas.73.8.2554. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harpel P. C. Studies on the interaction between collagen and a plasma kallikrein-like activity. Evidence for a surface-active enzyme system. J Clin Invest. 1972 Jul;51(7):1813–1822. doi: 10.1172/JCI106983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jain A. K. Cigarette smoking, use of oral contraceptives, and myocardial infarction. Am J Obstet Gynecol. 1976 Oct 1;126(3):301–307. doi: 10.1016/0002-9378(76)90539-1. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Levin J., Bang F. B. Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin. Thromb Diath Haemorrh. 1968 Mar 31;19(1):186–197. [PubMed] [Google Scholar]
- NIEWIAROWSKI S., PROU-WARTELLE O. [Role of the contact factor (Hageman factor) in fibrinolysis]. Thromb Diath Haemorrh. 1959 Sep 1;3:593–603. [PubMed] [Google Scholar]
- Ogston D., Bennett N. B., Ogston C. M., Ratnoff O. D. The assay of a plasma component necessary for the generation of a plasminogen activator in the presence of Hageman factor (Hageman factor co-factor). Br J Haematol. 1971 Feb;20(2):209–216. doi: 10.1111/j.1365-2141.1971.tb07029.x. [DOI] [PubMed] [Google Scholar]
- RATNOFF O. D., CRUM J. D. ACTIVATION OF HAGEMAN FACTOR BY SOLUTIONS OF ELLAGIC ACID. J Lab Clin Med. 1964 Mar;63:359–377. [PubMed] [Google Scholar]
- Strong J. P., Richards M. L., McGill H. C., Jr, Eggen D. A., McMurry M. T. On the association of cigarette smoking with coronary and aortic atherosclerosis. J Atheroscler Res. 1969 Nov-Dec;10(3):303–317. doi: 10.1016/s0368-1319(69)80034-7. [DOI] [PubMed] [Google Scholar]