Abstract
Antisera to the type-specific internal influenza virus matrix (M) protein of a type A influenza virus were produced in goats. In the presence of complement, anti-M serum was cytotoxic for target cells which were infected with a variety of serologically distinct type A influenza viruses, but did not react with type B influenza virus- infected cells. Absorption experiments indicated that anti-M serum detected a common antigen(s) on the surface of type A-infected cells. This serological cross-reactivity parallels the cross-reactivity observed for the cytotoxic T-cell response to type A viruses.
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- Barcinski M. A., Rosenthal A. S. Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells. J Exp Med. 1977 Mar 1;145(3):726–742. doi: 10.1084/jem.145.3.726. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burns W., Billups L. C., Notkins A. L. Thymus dependence of viral antigens. Nature. 1975 Aug 21;256(5519):654–656. doi: 10.1038/256654a0. [DOI] [PubMed] [Google Scholar]
- Doherty P. C., Blanden R. V., Zinkernagel R. M. Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant Rev. 1976;29:89–124. doi: 10.1111/j.1600-065x.1976.tb00198.x. [DOI] [PubMed] [Google Scholar]
- Doherty P. C., Effros R. B., Bennink J. Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1209–1213. doi: 10.1073/pnas.74.3.1209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Effros R. B., Doherty P. C., Gerhard W., Bennink J. Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses. J Exp Med. 1977 Mar 1;145(3):557–568. doi: 10.1084/jem.145.3.557. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein L. T., Klinman N. R., Manson L. A. A microtest radioimmunoassay for noncytotoxic tumor-specific antibody to cell-surface antigens. J Natl Cancer Inst. 1973 Nov;51(5):1713–1715. doi: 10.1093/jnci/51.5.1713. [DOI] [PubMed] [Google Scholar]
- HARBOE A. The influenza virus haemagglutinnation inhibition by antibody to host material. Acta Pathol Microbiol Scand. 1963;57:317–330. doi: 10.1111/j.1699-0463.1963.tb05101.x. [DOI] [PubMed] [Google Scholar]
- Janeway C. A., Jr The specificity of T lymphocyte responses to chemically defined antigens. Transplant Rev. 1976;29:164–188. doi: 10.1111/j.1600-065x.1976.tb00201.x. [DOI] [PubMed] [Google Scholar]
- Katz D. H., Benacerraf B. The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products. Transplant Rev. 1975;22:175–195. doi: 10.1111/j.1600-065x.1975.tb01559.x. [DOI] [PubMed] [Google Scholar]
- Laver W. G., Webster R. G. Preparation and immunogenicity of an influenza virus hemagglutinin and neuraminidase subunit vaccine. Virology. 1976 Feb;69(2):511–522. doi: 10.1016/0042-6822(76)90481-5. [DOI] [PubMed] [Google Scholar]
- Munro A. J., Taussig M. J. Two genes in the major histocompatibility complex control immune response. Nature. 1975 Jul 10;256(5513):103–106. doi: 10.1038/256103a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nowinski R. C., Watson A. Immune response of the mouse to the major core protein (p30) of ecotropic leukemia viruses. J Immunol. 1976 Aug;117(2):693–696. [PubMed] [Google Scholar]
- Oxford J. S., Schild G. C. Immunological and physicochemical studies of influenza matrix (M) polypeptides. Virology. 1976 Oct 15;74(2):394–402. doi: 10.1016/0042-6822(76)90345-7. [DOI] [PubMed] [Google Scholar]
- Rehn T. G., Inman J. K., Shearer G. M. Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds. J Exp Med. 1976 Oct 1;144(4):1134–1140. doi: 10.1084/jem.144.4.1134. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster R. G., Isachenko V. A., Carter M. A new avian influenza virus from feral birds in the USSR: recombination in nature? Bull World Health Organ. 1974;51(4):325–332. [PMC free article] [PubMed] [Google Scholar]