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. 1977 Nov 1;146(5):1367–1379. doi: 10.1084/jem.146.5.1367

Genetic control of cell-mediated responsiveness to an AKR tumor- associated antigen: mapping of the locus involved to the I region of the H-2 complex

PMCID: PMC2180965  PMID: 411874

Abstract

The role of H-2-linked genes in controlling resistance to murine leukemia viruses has been studied by measuring the cell-mediated immune response of F1 hybrid mice (between AKR and various C3H and C57BL/10 derived, H-2 congenic strains) to an AKR tumor cell line, BW5147. The studies have shown that the ability to generate a primary or secondary cell-mediated response to an AKR tumor cell antigenic determinant is under H-2 linked control. The locus determining CML responsiveness maps in the I-J subregion. Nonresponsiveness is associated with the H-2q/k and H-2b/k hybrid genotypes, whereas responsiveness is associated with the H-2k/k homozygous genotype. Nonresponsiveness may result from (a) dominant suppression; (b) recessive responsiveness; or (c) an alternate mechanism not yet understood. This type of control may be one of several H-2-associated mechanisms of defense against virus-induced neoplasms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aoki T., Boyse E. A., Old L. J. Occurrence of natural antibody to the G (gross) leukemia antigen in mice. Cancer Res. 1966 Jul;26(7):1415–1419. [PubMed] [Google Scholar]
  2. Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
  3. Chesebro B., Wehrly K., Stimpfling J. Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex. J Exp Med. 1974 Dec 1;140(6):1457–1467. doi: 10.1084/jem.140.6.1457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chesebro B., Wehrly K. Studies on the role of the host immune response in recovery from Friend virus leukemia. I. Antiviral and antileukemia cell antibodies. J Exp Med. 1976 Jan 1;143(1):73–84. doi: 10.1084/jem.143.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chesebro B., Wehrly K. Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity. J Exp Med. 1976 Jan 1;143(1):85–99. doi: 10.1084/jem.143.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Debré P., Kapp J. A., Dorf M. E., Benacerraf B. Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT). J Exp Med. 1975 Dec 1;142(6):1447–1454. doi: 10.1084/jem.142.6.1447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kapp J. A., Pierce C. W., Schlossman S., Benacerraf B. Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT). J Exp Med. 1974 Sep 1;140(3):648–659. doi: 10.1084/jem.140.3.648. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lilly F. The effect of histocompatibility-2 type on response to friend leukemia virus in mice. J Exp Med. 1968 Mar 1;127(3):465–473. doi: 10.1084/jem.127.3.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lilly F. The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529–539. doi: 10.1093/genetics/53.3.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lilly F. The role of genetics in Gross virus leukemogenesis. Bibl Haematol. 1970;(36):213–220. doi: 10.1159/000391710. [DOI] [PubMed] [Google Scholar]
  11. McDevitt H. O., Bodmer W. F. Protein clinical manifestations of primary tumors of the heart. Am J Med. 1972 Jan;52(1):1–8. doi: 10.1016/0002-9343(72)90002-2. [DOI] [PubMed] [Google Scholar]
  12. McDevitt H. O., Oldstone B. A., Pincus T. Histocompatibility-linked genetic control of specific immune responses to viral infection. Transplant Rev. 1974;19(0):209–225. doi: 10.1111/j.1600-065x.1974.tb00133.x. [DOI] [PubMed] [Google Scholar]
  13. Meruelo D., Leiberman M., Ginzton N., Deak B., McDevitt H. O. Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2. J Exp Med. 1977 Oct 1;146(4):1079–1087. doi: 10.1084/jem.146.4.1079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Murphy D. B., Herzenberg L. A., Okumura K., Herzenberg L. A., McDevitt H. O. A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med. 1976 Sep 1;144(3):699–712. doi: 10.1084/jem.144.3.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Nowinski R. C. Genetic control of natural immunity to ecotropic mouse leukemia viruses: immune response genes. Infect Immun. 1976 Apr;13(4):1098–1102. doi: 10.1128/iai.13.4.1098-1102.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Oldstone M. B., Dixon F. J., Mitchell G. F., McDevitt H. O. Histocompatibility-linked genetic control of disease susceptibility. Murine lymphocytic choriomeningitis virus infection. J Exp Med. 1973 May 1;137(5):1201–1212. doi: 10.1084/jem.137.5.1201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sato H., Boyse E. A., Aoki T., Iritani C., Old L. J. Leukemia-associated transplantation antigens related to murine leukemia virus. The X.1 system: immune response controlled by a locus linked to H-2. J Exp Med. 1973 Sep 1;138(3):593–606. doi: 10.1084/jem.138.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tada T., Taniguchi M., David C. S. Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex. J Exp Med. 1976 Sep 1;144(3):713–725. doi: 10.1084/jem.144.3.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tennant J. R., Snell G. D. The H-2 locus and viral leukemogenesis as studied in congenic strains of mice. J Natl Cancer Inst. 1968 Aug;41(2):597–604. [PubMed] [Google Scholar]
  20. Zwerner R. K., Acton R. T. Growth properties and alloantigenic expression of murine lymphoblastoid cell lines. J Exp Med. 1975 Aug 1;142(2):378–390. doi: 10.1084/jem.142.2.378. [DOI] [PMC free article] [PubMed] [Google Scholar]

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