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. 1977 Dec 1;146(6):1735–1747. doi: 10.1084/jem.146.6.1735

Recovery of avian sarcoma virus from tumors induced by transformation- defective mutants

PMCID: PMC2181894  PMID: 200700

Abstract

Transformation-defective (td) mutants of the Schmidt-Ruppin strain of Rous sarcoma virus (RSV), which contains deletions in the gene responsible for transformation (src gene), are unable to transform chicken embryo fibroblasts in vitro. Injection of some of these td mutants into newborn chickens resulted in the formation of sarcomas from which sarcoma virus was unfailingly recovered. The possibility that transforming RSV was present in the td virus preparations was excluded by further purification of the td viruses. Morphology of the foci induced by the newly recovered sarcoma virus was distinct from that of foci induced by the parental Schmidt Ruppin strain of RSV. It is suggested that the new sarcoma virus was generated as a result of the genetic interaction between the genomes of td virus and chicken cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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