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. 1977 Dec 1;146(6):1640–1647. doi: 10.1084/jem.146.6.1640

B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production

PMCID: PMC2181908  PMID: 303685

Abstract

The role played by macrophages in two effects of lipopolysaccharide (LPS) on the immune system of the mouse-substitution for helper T cells and induction of B-cell mitosis-has been investigated. C3H/HeJ mice are unresponsive and do not produce (as other strains do) antibody to 2,4,6- trinitrophenol (TNP) conjugated with autologous mouse erythrocytes (MRBC-TNP) in the presence of LPS. We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS- responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added. The mitotic response was not restored. The findings suggest that adjuvanticity and mitogenicity represent distinct pathways of B-cell activation by LPS, subject to different regulatory mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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