Abstract
Lewis rats given total lymphoid irradiation (TLI) accepted bone marrow allografts from AgB-incompatible donors. The chimeras showed no clinical signs of graft-versus-host disease. Skin allografts from the marrow donor strain survived for more than 150 days on the chimeras. However, third-party skin grafts were rejected promptly. Although heart allografts survived more than 300 days in Lewis recipients given TLI and bone marrow allografts, detectable levels of chimerism were not required for permanent survival.
Full Text
The Full Text of this article is available as a PDF (898.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Binz H., Wigzell H. Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors. J Exp Med. 1976 Dec 1;144(6):1438–1457. doi: 10.1084/jem.144.6.1438. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
- Dittmer J., Bennett M. Long-term survival of cardiac allografts in lethally irradiated rats repopulated with host-type hemopoietic cells. Transplantation. 1975 Apr;19(4):295–301. doi: 10.1097/00007890-197504000-00004. [DOI] [PubMed] [Google Scholar]
- Marquet R., Heystek G. The induction and abolition of specific immunosuppression of heart allografts in rats by use of donor blood and cyclophosphamide. J Immunol. 1975 Aug;115(2):405–408. [PubMed] [Google Scholar]
- Müller-Ruchholtz W., Wottge H. U., Müller-Hermelink H. K. Bone marrow transplantation in rats across strong histocompatibility barriers by selective elimination of lymphoid cells in donor marrow. Transplant Proc. 1976 Dec;8(4):537–541. [PubMed] [Google Scholar]
- Ono K., Lindsey E. S. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 1969 Feb;57(2):225–229. [PubMed] [Google Scholar]
- Slavin S., Strober S., Fuks Z., Kaplan H. S. Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts. J Exp Med. 1977 Jul 1;146(1):34–48. doi: 10.1084/jem.146.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Slavin S., Strober S., Fuks Z., Kaplan H. S. Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation. Science. 1976 Sep 24;193(4259):1252–1254. doi: 10.1126/science.785599. [DOI] [PubMed] [Google Scholar]
- Slavin S., Strober S., Fuks Z., Kaplan H. S. Use of total lymphoid irradiation in tissue transplantation in mice. Transplant Proc. 1977 Mar;9(1):1001–1004. [PubMed] [Google Scholar]
- Warren R. P., Lofgreen J. S., Steinmuller D. Differential survival of heart and skin allografts in inbred rats. Transplant Proc. 1973 Mar;5(1):717–719. [PubMed] [Google Scholar]