Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1978 Jul 1;148(1):103–114. doi: 10.1084/jem.148.1.103

Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells

PMCID: PMC2184917  PMID: 78954

Abstract

The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T- cell response which is specific for anti-major hostocompatibility complex receptors on parental T cells. This protective immunity is rapid in onset and once induced, it provides a highly effective, specific resistance to lethal GVH disease which is radioresistant and can be adoptively transferred to syngeneic recipients.

Full Text

The Full Text of this article is available as a PDF (751.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Binz H., Askonas B. A. Inhibition of mixed leukocyte culture by anti-idiotypic antibodies. Eur J Immunol. 1975 Sep;5(9):618–623. doi: 10.1002/eji.1830050908. [DOI] [PubMed] [Google Scholar]
  2. Binz H., Lindenmann J., Wigzell H. Inhibition of local graft-versus-host reaction by anti-alloantibodies. Nature. 1973 Nov 16;246(5429):146–148. doi: 10.1038/246146a0. [DOI] [PubMed] [Google Scholar]
  3. Binz H., Wigzell H. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. III. Physical fractionation of specific immunocompetent T lymphocytes by affinity chromatography using anti-idiotypic antibodies. J Exp Med. 1975 Nov 1;142(5):1231–1240. doi: 10.1084/jem.142.5.1231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cudkowicz G., Bennett M. Peculiar immunobiology of bone marrow allografts. II. Rejection of parental grafts by resistant F 1 hybrid mice. J Exp Med. 1971 Dec 1;134(6):1513–1528. doi: 10.1084/jem.134.6.1513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Elkins W. L. Cellular immunology and the pathogenesis of graft versus host reactions. Prog Allergy. 1971;15:78–187. [PubMed] [Google Scholar]
  6. Field E. O., Gibbs J. E. Effects of thymectomy and irradiation on graft-versus-host disease. Transplantation. 1965 Sep;3(5):634–638. doi: 10.1097/00007890-196509000-00005. [DOI] [PubMed] [Google Scholar]
  7. Ford W. L., Atkins R. C. Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1 hybrid rats. Nat New Biol. 1971 Dec 8;234(49):178–180. doi: 10.1038/newbio234178a0. [DOI] [PubMed] [Google Scholar]
  8. GOWANS J. L. The fate of parental strain small lymphocytes in F1 hybrid rats. Ann N Y Acad Sci. 1962 Oct 24;99:432–455. doi: 10.1111/j.1749-6632.1962.tb45326.x. [DOI] [PubMed] [Google Scholar]
  9. Howard J. C., Scott D. W. The identification of sera distinguishing marrow-derived and thymus-derived lymphocytes in the rat thoracic duct. Immunology. 1974 Nov;27(5):903–922. [PMC free article] [PubMed] [Google Scholar]
  10. Howard J. C. The life-span and recirculation of marrow-derived small lymphocytes from the rat thoracic duct. J Exp Med. 1972 Feb 1;135(2):185–199. doi: 10.1084/jem.135.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Howard J. C., Wilson D. B. Specific positive selection of lymphocytes reactive to strong histocompatibility antigens. J Exp Med. 1974 Sep 1;140(3):660–672. doi: 10.1084/jem.140.3.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  13. Krammer P. H. Alloantigen receptors on activated T cells in mice. I. Binding of alloantigens and anti-idiotypic antibodies to the same receptors. J Exp Med. 1978 Jan 1;147(1):25–36. doi: 10.1084/jem.147.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Krammer P. H., Eichmann K. T cell receptor idiotypes are controlled by genes in the heavy chain linkage group and the major histocompatibility complex. Nature. 1977 Dec 22;270(5639):733–735. doi: 10.1038/270733a0. [DOI] [PubMed] [Google Scholar]
  15. Marshak A., Doherty P. C., Wilson D. B. The control of specificity of cytotoxic T lymphocytes by the major histocompatibility complex (AG-B) in rats and identification of a new alloantigen system showing no AG-B restriction. J Exp Med. 1977 Dec 1;146(6):1773–1790. doi: 10.1084/jem.146.6.1773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Martin W. J. Assay for the immunosuppressive capacity of antilymphocyte serum. I. Evidence for opsonization. J Immunol. 1969 Nov;103(5):979–989. [PubMed] [Google Scholar]
  17. McCullagh P. Anti-parental-strain lymphocyte responsiveness of F1 hybrid-strain lymphocytes. Scand J Immunol. 1977;6(10):967–980. doi: 10.1111/j.1365-3083.1977.tb00332.x. [DOI] [PubMed] [Google Scholar]
  18. McCullagh P. Modification of the responsiveness of F1 hybrid rats to lymphocytes from parental strain rats. Aust J Exp Biol Med Sci. 1973 Dec;51(6):753–771. doi: 10.1038/icb.1973.72. [DOI] [PubMed] [Google Scholar]
  19. McKearn T. J., Hamada Y., Stuart F. P., Fitch F. W. Anti-receptor antibody and resistance to graft-versus-host disease. Nature. 1974 Oct 18;251(5476):648–650. doi: 10.1038/251648a0. [DOI] [PubMed] [Google Scholar]
  20. Ramseier H., Lindenmann J. F1 hybrid animals: reactivity against recognition structures of parental strain lymphoid cells. Pathol Microbiol (Basel) 1969;34(6):379–387. doi: 10.1159/000162189. [DOI] [PubMed] [Google Scholar]
  21. SCHWARTZ E. E., UPTON A. C., CONGDON C. C. A fatal reaction caused by implantation of adult parental spleen tissue in irradiated F1 mice. Proc Soc Exp Biol Med. 1957 Dec;96(3):797–800. doi: 10.3181/00379727-96-23612. [DOI] [PubMed] [Google Scholar]
  22. Shearer G. M., Cudkowicz G. Induction of F1 hybrid antiparent cytotoxic effector cells: an in vitro model for hemopoietic histoincompatibility. Science. 1975 Nov 28;190(4217):890–893. doi: 10.1126/science.1188368. [DOI] [PubMed] [Google Scholar]
  23. Wilson D. B., Marshak A., Howard J. C. SPECIFIC positive and negative selection of rat lymphocytes reactive to strong histocompatibility antigens: activation with alloantigens in vitro and in vivo. J Immunol. 1976 Apr;116(4):1030–1040. [PubMed] [Google Scholar]
  24. Woodland R. T., Wilson D. B. The induction of specific resistance in F1 hybrid rats to local graft-vs.-host reactions: nature of the eliciting cell. Eur J Immunol. 1977 Mar;7(3):136–142. doi: 10.1002/eji.1830070305. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES