Abstract
By using a culture system that allows the segregation of individual precursors of cytotoxic lymphocytes, the number of clones generated by cells from different combinations of congenic mice have been measured. It has been found that 0.3% of the total anti-H2d clones are generated by stimulators which differ predominantly at the H-2 locus. The contribution of non-H-2 antigens to anti-H-2 responses is discussed.
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Selected References
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- Bach F. H., Bach M. L., Sondel P. M. Differential function of major histocompatibility complex antigens in T-lymphocyte activation. Nature. 1976 Jan 29;259(5541):273–281. doi: 10.1038/259273a0. [DOI] [PubMed] [Google Scholar]
- Bevan M. J. Cytotoxic t-cell response to histocompatibility antigens: the role of H-2. Cold Spring Harb Symp Quant Biol. 1977;41(Pt 2):519–527. doi: 10.1101/sqb.1977.041.01.060. [DOI] [PubMed] [Google Scholar]
- Ching L. M., Marbrook J., Walker K. Z. Spontaneous clones of cytotoxic T cells in culture. II. Specificity of the response. Cell Immunol. 1977 Jun 15;31(2):293–301. doi: 10.1016/0008-8749(77)90030-2. [DOI] [PubMed] [Google Scholar]
- Ford W. L., Simmonds S. J., Atkins R. C. Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex. J Exp Med. 1975 Mar 1;141(3):681–696. doi: 10.1084/jem.141.3.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gordon R. D., Simpson E., Samelson L. E. In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice. J Exp Med. 1975 Nov 1;142(5):1108–1120. doi: 10.1084/jem.142.5.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Janeway C. A., Wigzell H., Binz H. Two different VH gene products make up the T-cell receptors. Scand J Immunol. 1976;5(9):993–1001. doi: 10.1111/j.1365-3083.1976.tb03051.x. [DOI] [PubMed] [Google Scholar]
- Lindahl K. F., Wilson D. B. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors. J Exp Med. 1977 Mar 1;145(3):508–522. doi: 10.1084/jem.145.3.508. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Quintáns J., Lefkovits I. Precursor cells specific to sheep red cells in nude mice. Estimation of frequency in the microculture system. Eur J Immunol. 1973 Jul;3(7):392–397. doi: 10.1002/eji.1830030704. [DOI] [PubMed] [Google Scholar]
- Schrader J. W., Cunningham B. A., Edelman G. M. Functional interactions of viral and histocompatibility antigens at tumor cell surfaces. Proc Natl Acad Sci U S A. 1975 Dec;72(12):5066–5070. doi: 10.1073/pnas.72.12.5066. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Skinner M. A., Marbrook J. An estimation of the frequency of precursor cells which generate cytotoxic lymphocytes. J Exp Med. 1976 Jun 1;143(6):1562–1567. doi: 10.1084/jem.143.6.1562. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilson D. B., Blyth JL NOWELL P. C. Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response. J Exp Med. 1968 Nov 1;128(5):1157–1181. doi: 10.1084/jem.128.5.1157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilson D. B., Blyth JL NOWELL P. C. Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response. J Exp Med. 1968 Nov 1;128(5):1157–1181. doi: 10.1084/jem.128.5.1157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilson D. B., Heber-Katz E., Sprent J., Howard J. C. On the possibility of multiple t-cell receptors. Cold Spring Harb Symp Quant Biol. 1977;41(Pt 2):559–561. doi: 10.1101/sqb.1977.041.01.064. [DOI] [PubMed] [Google Scholar]
- Zinkernagel R. M., Doherty P. C. Major transplantation antigens, viruses, and specificity of surveillance T cells. Contemp Top Immunobiol. 1977;7:179–220. doi: 10.1007/978-1-4684-3054-7_5. [DOI] [PubMed] [Google Scholar]
