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. 1978 Jul 1;148(1):128–135. doi: 10.1084/jem.148.1.128

T-cell populations specifically depleted of alloreactive potential cannot be induced to lyse H-2-different virus-infected target cells

PMCID: PMC2184928  PMID: 78955

Abstract

Mouse lymphocyte populations of one parental H-2 type (A) were specificially depleted of alloreactive potential by filtration through irradiated A X B F1 recipients, and thoracic duct cells were then stimulated with virus in an A X B F1 environment. Experiments using T cells that had previously been exposed to influenza virus in the context of A established that cross-priming for recognition of viral components expressed on H-2-different (B) target cells does not occur. Furthermore, immunologically naive T cells stimulated with vaccinia virus, subsequent to negative selection for reactivity to B, could not be shown to interact with virus-infected cells of type B. Either there is no significant T-cell repertoire for recognition of virus associated with an H-2 determinant not encountered during ontogeny, or such T cells are also alloreactive and are removed during filtration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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