Abstract
BALB/c mice were inoculated subcutaneously with 10(6) cells from either of two syngeneic sarcomas 1315 and 1425. 6--8 days later, the mice were randomized into groups which were left untreated or given 400 rads of whole body irradiation. Irradiation significantly retarded the growth of both sarcomas, and complete regressions were seen of approximately equal to 30% of the small, established 1315 tumors. The anti-tumor effect of irradiation was abolished if the irradiated mice were inoculated with a T-cell-enriched (but not with a T-cell deprived) suspension of syngeneic spleen cells, suggesting that the irradiation inhibited tumor growth by affecting a radiosensitive population of host suppressor T cells.
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Selected References
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- Belehradek J., Jr, Barski G., Thonier M. Evolution of cell-mediated antitumor immunity in mice bearing a syngeneic chemically induced tumor. Influence of tumor growth, surgical removal and treatment with irradiated tumor cells. Int J Cancer. 1972 May 15;9(3):461–469. doi: 10.1002/ijc.2910090302. [DOI] [PubMed] [Google Scholar]
- Brown J. P., Klitzman J. M., Hellström I., Nowinski R. C., Hellström K. E. Antibody response of mice to chemically induced tumors. Proc Natl Acad Sci U S A. 1978 Feb;75(2):955–958. doi: 10.1073/pnas.75.2.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dutton R. W. Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity. J Exp Med. 1972 Dec 1;136(6):1445–1460. doi: 10.1084/jem.136.6.1445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fujimoto S., Greene M. I., Sehon A. H. Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor cells in tumor-bearing hosts. J Immunol. 1976 Mar;116(3):800–806. [PubMed] [Google Scholar]
- Gershon R. K., Mokyr M. B., Mitchell M. S. Activation of suppressor T cells by tumour cells and specific antibody. Nature. 1974 Aug 16;250(467):594–596. doi: 10.1038/250594a0. [DOI] [PubMed] [Google Scholar]
- Greene M. I., Dorf M. E., Pierres M., Benacerraf B. Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5118–5121. doi: 10.1073/pnas.74.11.5118. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greene M. I., Fujimoto S., Sehon A. H. Regulation of the immune response to tumor antigens. III. Characterization of thymic suppressor factor(s) produced by tumor-bearing hosts. J Immunol. 1977 Aug;119(2):757–764. [PubMed] [Google Scholar]
- Hayami M., Hellström I., Hellström K. E., Yamanouchi K. Cell-mediated destruction of Rous sarcomas in Japanese quails. Int J Cancer. 1972 Nov;10(3):507–517. doi: 10.1002/ijc.2910100309. [DOI] [PubMed] [Google Scholar]
- Hellström K. E., Hellström I., Brown J. P. Unique and common tumor-specific transplantation antigens of chemically induced mouse sarcomas. Int J Cancer. 1978 Mar 15;21(3):317–322. doi: 10.1002/ijc.2910210311. [DOI] [PubMed] [Google Scholar]
- Howell S. B., Dean J. H., Law L. W. Defects in cell-mediated immunity during growth of a syngeneic simian virus-induced tumor. Int J Cancer. 1975 Jan 15;15(1):152–169. doi: 10.1002/ijc.2910150118. [DOI] [PubMed] [Google Scholar]
- Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
- Prehn R. T. The immune reaction as a stimulator of tumor growth. Science. 1972 Apr 14;176(4031):170–171. doi: 10.1126/science.176.4031.170. [DOI] [PubMed] [Google Scholar]
- Reinisch C. L., Andrew S. L., Schlossman S. F. Suppressor cell regulation of immune response to tumors: abrogation by adult thymectomy. Proc Natl Acad Sci U S A. 1977 Jul;74(7):2989–2992. doi: 10.1073/pnas.74.7.2989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Röllinghoff M., Starzinski-Powitz A., Pfizenmaier K., Wagner H. Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes. J Exp Med. 1977 Feb 1;145(2):455–459. doi: 10.1084/jem.145.2.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schechter B., Feldman M. Hydrocortisone affects tumor growth by eliminating precursors of suppressor cells. J Immunol. 1977 Nov;119(5):1563–1568. [PubMed] [Google Scholar]