Abstract
Age-related concentrations of myelin basic protein serum factor (MBP- SF), an endogenous neuroantigen detected and quantitated by inhibition of binding of rat myelin basic protein (RMBP) antibody with 125I-RMBP reagent antigen and immunochemically indistinguishable from native RMBP in this respect, reach peak levels as high as 21 ng/microliter among 2- 3-wk-old normal suckling Lewis rats. Levels then progressively decline to low, usually undetectable levels of less than or equal to 0.6 ng/microliter MBP-equivalents in adult animals by 7 wk of age. MBP-SF levels are inversely related to the age-related increasing capacity of maturing Lewis rats to develop experimental allergic encephalomyelitis (EAE) after sensitization to MBP of syngeneic, but not xenogeneic, origin. MBP-SF appears to be an endogenous neuroimmunoregulatory product of potential importance for immunologic tolerance to autologous RMBP in Lewis rats.
Full Text
The Full Text of this article is available as a PDF (328.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cohen I. R., Wekerle H. Regulation of autosensitization. The immune activation and specific inhibition of self-recognizing thymus-derived lymphocytes. J Exp Med. 1973 Feb 1;137(2):224–238. doi: 10.1084/jem.137.2.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dal Canto M. C., Fujinami R. S., Paterson P. Y. Experimental allergic encephalomyelitis in suckling Lewis rats: comparison with the disease in adult animals. Lab Invest. 1977 Oct;37(4):395–405. [PubMed] [Google Scholar]
- Day E. D., Varitek V. A., Fujinami R. S., Paterson P. Y. MBP-SF, a prominent serum factor in suckling Lewis rats that additively inhibits the primary binding of myelin basic protein (MBP) to syngeneic anti-MBP antibodies. Immunochemistry. 1978 Jan;15(1):1–9. doi: 10.1016/0161-5890(78)90018-4. [DOI] [PubMed] [Google Scholar]
- Day E. D., Varitek V. A., Paterson P. Y. Myelin basic protein serum factor (MBP-SF) in adult Lewis rats: a method for detection and evidence that MBP-SF influences the appearance of antibody to MBP in animals developing experimental allergic encephalomyelitis. Immunochemistry. 1978 Jul;15(7):437–442. doi: 10.1016/0161-5890(78)90071-8. [DOI] [PubMed] [Google Scholar]
- Deibler G. E., Martenson R. E., Kies M. W. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep Biochem. 1972;2(2):139–165. doi: 10.1080/00327487208061467. [DOI] [PubMed] [Google Scholar]
- Fujinami R. S., Paterson P. Y. Induction of experimental allergic encephalomyelitis in suckling Lewis rats: role of age and type of sensitizing neuroantigen. J Immunol. 1977 Nov;119(5):1634–1638. [PubMed] [Google Scholar]
- Orgad S., Cohen I. R. Autoimmune encephalomyelitis: activation of thymus lymphocytes against syngeneic brain antigens in vitro. Science. 1974 Mar 15;183(4129):1083–1085. doi: 10.1126/science.183.4129.1083. [DOI] [PubMed] [Google Scholar]
- PATERSON P. Y., HARWIN S. M. Suppression of allergic encephalomyelitis in rats by means of antibrain serum. J Exp Med. 1963 May 1;117:755–774. doi: 10.1084/jem.117.5.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pitts O. M., Varitek V. A., Day E. D. The extensive cross-reaction of several syngeneic rat-anti-BP antiserums with myelin basic proteins (BP) of other species. Immunochemistry. 1976 Apr;13(4):307–312. doi: 10.1016/0019-2791(76)90339-6. [DOI] [PubMed] [Google Scholar]
- Spitler L. E., Von Muller C. M., Fudenberg H. H., Eylar E. H. Experimental allergic encephalitis. Dissociation of cellular immunity to brain protein and disease production. J Exp Med. 1972 Jul 1;136(1):156–174. doi: 10.1084/jem.136.1.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steinman L., Cohen I. R., Teitelbaum D., Arnon R. Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-association and soluble antigen. Nature. 1977 Jan 13;265(5590):173–175. doi: 10.1038/265173a0. [DOI] [PubMed] [Google Scholar]
- Weigle W. O. Immunological unresponsiveness. Adv Immunol. 1973;16:61–122. doi: 10.1016/s0065-2776(08)60296-5. [DOI] [PubMed] [Google Scholar]