Abstract
Long surviving, passively enhanced (AS X AUG)F1 kidneys carried by AS recipients were retransplanted into (AS X WF)F1 second hosts. Acute graft rejection did not occur. Only one of six secondary recipients mounted a significant T-dependent IgG lymphocytotoxic antibody response. In all six, generation of cytotoxic T cells was markedly slower and depressed. These results are compatible with the hypothesis that kidney parenchyma, although carrying major histocompatibility complex specificity is able to induce T-independent but not T-dependent alloimmunity. A corollary is that passenger cells are responsible for exciting the T-dependent allimmune response normally observed after grafing. The practical difficulty of eliminating all T-dependent immunogenicity from (AS X AUG)F1 kidneys was emphasized by the observation that a 3-d residence in an intermediate AS recipient was insufficient time to prevent acute graft rejection after retransplantation.
Full Text
The Full Text of this article is available as a PDF (280.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Batchelor J. R., Welsh K. I., Maynard A., Burgos H. Failure of long surviving, passively enhanced kidney allografts to provoke T-dependent alloimmunity. I. Retransplantation of (AS X AUG)F1 kidneys into secondary AS recipients. J Exp Med. 1979 Sep 19;150(3):455–464. doi: 10.1084/jem.150.3.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- French M. E., Batchelor J. R. Immunological enhancement of rat kidney grafts. Lancet. 1969 Nov 22;2(7630):1103–1106. doi: 10.1016/s0140-6736(69)90705-3. [DOI] [PubMed] [Google Scholar]
- Guttmann R. D., Beaudoin J. G., Morehouse D. D. Reduction of immunogenicity of human cadaver renal allografts by donor pretreatment. Transplant Proc. 1973 Mar;5(1):663–665. [PubMed] [Google Scholar]
- Lafferty K. J., Woolnough J. The origin and mechanism of the allograft reaction. Immunol Rev. 1977;35:231–262. doi: 10.1111/j.1600-065x.1977.tb00241.x. [DOI] [PubMed] [Google Scholar]
- Sollinger H. W., Bach F. H. Collaboration between in vivo responses to LD and SD antigens of major histocompatibility complex. Nature. 1976 Feb 12;259(5543):487–488. doi: 10.1038/259487a0. [DOI] [PubMed] [Google Scholar]