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. 1979 Sep 19;150(3):455–464. doi: 10.1084/jem.150.3.455

Failure of long surviving, passively enhanced kidney allografts to provoke T-dependent alloimmunity. I. Retransplantation of (AS X AUG)F1 kidneys into secondary AS recipients

PMCID: PMC2185654  PMID: 383874

Abstract

Long survival of (AS X AUG)F1 rat kidney allografts in AS recipients was induced by passive enhancement with AS anti-AUG antiserum at the time of grafting. After 1-3 mo, the kidney allografts were transferred to second AS recipients, either naive or sensitized against AUG tissue. Naive second recipients did not reject the grafts acutely and failed to mount T-dependent immunity against AUG targets. When later challenged with spleen cells carrying the AUG haplotype, the naive second AS recipients showed strong IgM, IgG, and cytotoxic T-cell responses after grafting, and the kidneys were rapidly destroyed by immune rejection in all but one rat. It is concluded that long-surviving kidney allografts fail to activate helper T cells and induce in naive second recipients the same state of unresponsiveness observed in the first recipient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach F. H., Bach M. L., Sondel P. M. Differential function of major histocompatibility complex antigens in T-lymphocyte activation. Nature. 1976 Jan 29;259(5541):273–281. doi: 10.1038/259273a0. [DOI] [PubMed] [Google Scholar]
  2. Batchelor J. R., Welsh K. I., Burgos H. Humoral factors. Immunologic enhancement. Transplant Proc. 1977 Mar;9(1):931–936. [PubMed] [Google Scholar]
  3. Burgos H., French M. E., Batchelor J. R. Humoral and cell-mediated immunity in rats with enhanced kidney allografts. Transplantation. 1974 Oct;18(4):328–335. doi: 10.1097/00007890-197410000-00005. [DOI] [PubMed] [Google Scholar]
  4. Cantor H., Boyse E. A. Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity. J Exp Med. 1975 Jun 1;141(6):1390–1399. doi: 10.1084/jem.141.6.1390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cantor H., Boyse E. A. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J Exp Med. 1975 Jun 1;141(6):1376–1389. doi: 10.1084/jem.141.6.1376. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fabre J. W., Morris P. J. The mechanism of specific immunosuppression of renal allograft rejection by donor strain blood. Transplantation. 1972 Nov;14(5):634–640. doi: 10.1097/00007890-197211000-00016. [DOI] [PubMed] [Google Scholar]
  7. Fine R. N., Batchelor J. R., French M. E., Shumak K. H. The uptake of 125I-labeled rat alloantibody and its loss after combination with antigen. Transplantation. 1973 Dec;16(6):641–648. doi: 10.1097/00007890-197312000-00016. [DOI] [PubMed] [Google Scholar]
  8. French M. E. Antibody turnover by enhanced rat kidneys. Transplant Proc. 1973 Mar;5(1):621–623. [PubMed] [Google Scholar]
  9. French M. E., Batchelor J. R. Enhancement of renal allografts in rats and man. Transplant Rev. 1972;13:115–141. doi: 10.1111/j.1600-065x.1972.tb00062.x. [DOI] [PubMed] [Google Scholar]
  10. French M. E., Batchelor J. R. Immunological enhancement of rat kidney grafts. Lancet. 1969 Nov 22;2(7630):1103–1106. doi: 10.1016/s0140-6736(69)90705-3. [DOI] [PubMed] [Google Scholar]
  11. Häyry P., Anderson L. C. Generation of T memory cells in one-way mixed lymphocyte culture. IV. Primary and secondary responses to soluble and insoluble membrane preparations and to ultraviolet-light-inactivated stimulator cells. Scand J Immunol. 1976;5(4):391–399. doi: 10.1111/j.1365-3083.1976.tb00293.x. [DOI] [PubMed] [Google Scholar]
  12. Klein J., Livnat S., Hauptfeld V., Jerábek L., Weissman I. Production of anti-H-2 antibodies in thymectomized mice. Eur J Immunol. 1974 Jan;4(1):41–44. doi: 10.1002/eji.1830040111. [DOI] [PubMed] [Google Scholar]
  13. Lafferty K. J., Woolnough J. The origin and mechanism of the allograft reaction. Immunol Rev. 1977;35:231–262. doi: 10.1111/j.1600-065x.1977.tb00241.x. [DOI] [PubMed] [Google Scholar]
  14. Mullen Y., Takasugi M., Hildemann W. H. The immunological status of rats with long surviving (enhanced) kidney allografts. Transplantation. 1973 Feb;15(2):238–246. doi: 10.1097/00007890-197302000-00008. [DOI] [PubMed] [Google Scholar]
  15. Poole M., Bowen J. E., Batchelor J. R. Prolonged survival of rat leg allografts due to immunological enhancement. Transplantation. 1976 Aug;22(2):108–111. doi: 10.1097/00007890-197608000-00005. [DOI] [PubMed] [Google Scholar]
  16. Rolstad B., Williams A. F., Ford W. L. The alloantibody response to a strong transplantation antigen (Ag-B). Quantitative aspects and thymus dependence of the response. Transplantation. 1974 Apr;17(4):416–423. doi: 10.1097/00007890-197404000-00013. [DOI] [PubMed] [Google Scholar]
  17. Ruszkiewicz M. Complement-activating properties of some rat alloantibodies. Transplantation. 1975 Sep;20(3):227–236. doi: 10.1097/00007890-197509000-00007. [DOI] [PubMed] [Google Scholar]
  18. Stingl G., Katz S. I., Clement L., Green I., Shevach E. M. Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol. 1978 Nov;121(5):2005–2013. [PubMed] [Google Scholar]
  19. Stuart F. P., Bastien E., Holter A., Fitch F. W., Elkins W. L. Role of passenger leukocytes in the rejection of renal allografts. Transplant Proc. 1971 Mar;3(1):461–464. [PubMed] [Google Scholar]
  20. Stuart F. P., Fitch F. W., Rowley D. A. Specific suppression of renal allograft rejection by treatment with antigen and antibody. Transplant Proc. 1970 Dec;2(4):483–488. [PubMed] [Google Scholar]
  21. Welsh K. I., Burgos H., Batchelor J. R. The immune response to allogeneic rat platelets; Ag-B antigens in matrix form lacking Ia. Eur J Immunol. 1977 May;7(5):267–272. doi: 10.1002/eji.1830070505. [DOI] [PubMed] [Google Scholar]

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