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. 1980 Mar 1;151(3):517–527. doi: 10.1084/jem.151.3.517

Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor

PMCID: PMC2185813  PMID: 6766980

Abstract

Cellular events mediated by antigen-specific soluble factor extracted from carrier-primed suppressor T cells (TsF) in the suppressive interaction was studied. Keyhole limpet hemocyanin (KLH)-specific TsF directly acts on KLH-primed, I-J positive, nylon-wool-adherent T cells that have an acceptor site for TsF. The nylon-wool-adherent T cells, after accepting TsF in the presence of specific antigen, generate new suppressor T cells acting as an actual effector cell type. Antigen- specificity and syngeneity at I-J between TsF and acceptor T cells are both required for the induction of new suppressor T cells. Newly induced suppressor T cells, however, suppress both syngeneic and allogeneic responses in an antigen-nonspecific fashion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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