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. 1980 May 1;151(5):1305–1310. doi: 10.1084/jem.151.5.1305

Generation of primary cytotoxic lymphocytes against non-major histocompatibility complex antigens by anti-Ia serum plus complement- treated lymphocytes

PMCID: PMC2185853  PMID: 7373222

Abstract

The results presented in this paper demonstrate that responding cells that remain after anti-Ia serum plus complement (C) treatment generate a highly significant in vitro cytotoxic response against minor histocompatibility complex antigens. The cytotoxic response appears to be antigen specific in that target cells of strains other than the sensitizing strain are not lysed, or lysed to a lesser extent. The cytotoxic cells are susceptible to anti-Thy-1 plus C lysis. Anti-Ia serum may function by removing an unprimed suppressor cell, although other mechanisms cannot be ruled out.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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